R-loops are three-stranded structures that harbour an RNA–DNA hybrid and frequently form
during transcription. R-loop misregulation is associated with DNA damage, transcription …

Despite a lack of recent progress in the treatment of schizophrenia, our understanding of its
genetic and environmental causes has considerably improved, and their relationship to …

Abstract R-loops are DNA–RNA hybrids enriched at CpG islands (CGIs) that can regulate
chromatin states,,,,,,–. How R-loops are recognized and interpreted by specific epigenetic …

Reactive oxygen species continuously assault the structure of DNA resulting in oxidation
and fragmentation of the nucleobases. Both oxidative DNA damage itself and its repair …

Cytosine methylation in CpG dinucleotides is an epigenetic DNA modification dynamically
established and maintained by DNA methyltransferases and demethylases. Molecular …

DNA demethylation can occur passively by “dilution” of methylation marks by DNA
replication, or actively and independently of DNA replication. Direct conversion of 5 …

DNA methylation plays an important role in the maintenance of genomic stability. Ten-
eleven translocation proteins (TETs) are a family of iron (Fe2+) and α-KG-dependent …

DNA cytosine methylation plays a vital role in repressing retrotransposons, and such
derepression is linked with developmental failure, tumorigenesis and aging. DNA …

Post-fertilization epigenome reprogramming erases epigenetic marks transmitted through
gametes and establishes new marks during mid-blastula stages. The mouse embryo …

Aims Epicardium and epicardium-derived cells are critical players in myocardial fibrosis.
Mesenchymal stem cell–derived extracellular vesicles (EVs) have been studied for cardiac …