Although oxygen therapy has been used in the care of critically ill patients for many years,
the recognition of pulmonary oxygen toxicity as an important clinical problem is relatively …

The “free radical theory of oxygen toxicity” attributes the damaging effects of hyperoxia to
highly-reactive metabolic products of oxygen (O 2) that can inactivate enzymes in the cell …

Lung capillary endothelial cells (ECs) are a critical target of oxygen toxicity and play a
central role in the pathogenesis of hyperoxic lung injury. To determine mechanisms and time …

Breathing pure oxygen at 1 atmosphere pressure causes significant damage to respiratory
tissue of monkeys. Alveolar lining epithelium is almost completely destroyed after 4 days …

Rats were exposed to 98.5% oxygen at 765 torr for 6–72 hr. The pulmonary changes were
investigated by electron microscopy and by morphometric methods. A progressive …

Oxygen supplementation is one of the most common interventions in critically ill patients.
Despite over a century of data suggesting both beneficial and detrimental effects of …

Oxygen is one of the most widely available and used therapeutic agents in the world.
However, it is all too easy forget that oxygen is a prescribable drug with specific biochemical …

For most living beings, oxygen is an essential molecule for survival, being the basis of
biological oxidations, which satisfy most of the energy needs of aerobic organisms. Oxygen …

Background The role of supplemental oxygen therapy in the healing of esophagojejunal
anastomosis is still very much in an experimental stage. The aim of the present prospective …

Over the past decade, the interest in oxygen toxicity has led to various observational studies
and randomized clinical trials in critically ill patients, assessing the association with …