[HTML][HTML] Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies

S Xu, I Ilyas, J Weng - Acta Pharmacologica Sinica, 2023 - nature.com
The fight against coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is
still raging. However, the pathophysiology of acute and post-acute manifestations of COVID …

[HTML][HTML] Metformin: update on mechanisms of action and repurposing potential

M Foretz, B Guigas, B Viollet - Nature Reviews Endocrinology, 2023 - nature.com
Currently, metformin is the first-line medication to treat type 2 diabetes mellitus (T2DM) in
most guidelines and is used daily by> 200 million patients. Surprisingly, the mechanisms …

[HTML][HTML] Metformin: Is it a drug for all reasons and diseases?

CR Triggle, I Mohammed, K Bshesh, I Marei, K Ye… - Metabolism, 2022 - Elsevier
Metformin was first used to treat type 2 diabetes in the late 1950s and in 2022 remains the
first-choice drug used daily by approximately 150 million people. An accumulation of …

[HTML][HTML] COVID-19 and diabetes mellitus: from pathophysiology to clinical management

S Lim, JH Bae, HS Kwon, MA Nauck - Nature Reviews Endocrinology, 2021 - nature.com
Initial studies found increased severity of coronavirus disease 2019 (COVID-19), caused by
infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in patients …

COVID-19 and metabolic disease: mechanisms and clinical management

C Steenblock, PEH Schwarz, B Ludwig… - The lancet Diabetes & …, 2021 - thelancet.com
Up to 50% of the people who have died from COVID-19 had metabolic and vascular
disorders. Notably, there are many direct links between COVID-19 and the metabolic and …

[HTML][HTML] Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease

L Bergamaschi, F Mescia, L Turner, AL Hanson… - Immunity, 2021 - cell.com
The kinetics of the immune changes in COVID-19 across severity groups have not been
rigorously assessed. Using immunophenotyping, RNA sequencing, and serum cytokine …

[HTML][HTML] COVID-19 and diabetes: understanding the interrelationship and risks for a severe course

CP Landstra, EJP de Koning - Frontiers in endocrinology, 2021 - frontiersin.org
The relationship between COVID-19 and diabetes mellitus is complicated and bidirectional.
On the one hand, diabetes mellitus is considered one of the most important risk factors for a …

[HTML][HTML] Diabetes, obesity, metabolism, and SARS-CoV-2 infection: the end of the beginning

DJ Drucker - Cell metabolism, 2021 - cell.com
The increased prevalence of obesity, diabetes, and cardiovascular risk factors in people
hospitalized with severe COVID-19 illness has engendered considerable interest in the …

Prescription of glucose-lowering therapies and risk of COVID-19 mortality in people with type 2 diabetes: a nationwide observational study in England

K Khunti, P Knighton, F Zaccardi, C Bakhai… - The lancet Diabetes & …, 2021 - thelancet.com
Background In patients with type 2 diabetes, hyperglycaemia is an independent risk factor
for COVID-19-related mortality. Associations between pre-infection prescription for glucose …

[HTML][HTML] Management of diabetes and hyperglycaemia in the hospital

FJ Pasquel, MC Lansang, K Dhatariya… - The lancet Diabetes & …, 2021 - thelancet.com
Hyperglycaemia in people with and without diabetes admitted to the hospital is associated
with a substantial increase in morbidity, mortality, and health-care costs. Professional …