Cellular senescence is a cell cycle arrest in damaged or aged cells. Although this represents
a critical mechanism of tumor suppression, persistence of senescent cells during aging …

Neovascularization and angiogenesis are vital processes in the repair of damaged tissue,
creating new blood vessel networks and increasing oxygen and nutrient supply for …

Stem cell therapy is promising for neural repair in devastating traumatic brain injury (TBI).
However, the low survival and differentiation rates of transplanted stem cells are main …

Mesenchymal stem cells (MSCs) have putative roles in maintaining adult tissue health, and
the functional decline of MSCs has emerged as a crucial pathophysiological driver of …

Highlights•Environmental factors influence the development of clonal hematopoiesis.•
Inflammation exerts a strong influence on hematopoietic stem cell biology and may serve as …

With aging, hematopoietic stem cells (HSCs) have an impaired ability to regenerate,
differentiate, and produce an entire repertoire of mature blood and immune cells. Owing to …

Age-associated bone diseases such as osteoporosis (OP) are common in the elderly due to
skeletal ageing. The process of skeletal ageing can be accelerated by reduced proliferation …

Advanced age is a shared risk factor for many chronic and debilitating skeletal diseases
including osteoporosis and periodontitis. Mesenchymal stem cells develop various aging …

Bone marrow (BM) is a heterogeneous niche where bone marrow stromal cells (BMSCs),
osteoblasts, osteoclasts, adipocytes, hematopoietic cells, and immune cells coexist. The …

Quiescent state has been observed in stem cells (SCs), including in adult SCs and in cancer
SCs (CSCs). Quiescent status of SCs contributes to SC self-renewal and conduces to …