Covering 2000 to June 2015 This review discusses the biosynthesis of natural products that
are generated by trans-AT polyketide synthases, a family of catalytically versatile enzymes …

Membrane lipid homeostasis is a vital facet of bacterial cell physiology. For decades,
research in bacterial lipid synthesis was largely confined to the Escherichia coli model …

Multi-drug resistant pathogens have become a major threat to human health and new
antibiotics are urgently needed. Most antibiotics are derived from secondary metabolites …

Covering: 2000 to 2019 Natural products (NPs) are important sources of human therapeutic
agents and pesticides. To prevent self-harm from bioactive NPs, some microbial producers …

The rationale for the pursuit of bacterial type 2 fatty acid synthesis (FASII) as a target for
antibacterial drug discovery in Gram-positive organisms is being debated vigorously based …

Antibiotic resistance poses a tremendous threat to human health. To overcome this problem,
it is essential to know the mechanism of antibiotic resistance in antibiotic-producing and …

Covering: up to 2017 The overwhelming majority of antibiotics in clinical use originate from
Gram-positive Actinobacteria. In recent years, however, Gram-negative bacteria have …

The emergence of resistance against most current drugs emphasizes the need to develop
new approaches to control bacterial pathogens, particularly Staphylococcus aureus …

Antibiotic resistance is a serious public health concern, and new drugs are needed to
ensure effective treatment of many bacterial infections. Bacterial type II fatty acid synthesis …

Bacterial fatty acid synthesis is essential for many pathogens and different from the
mammalian counterpart. These features make bacterial fatty acid synthesis a desirable …