Small proteins; big questions

T Gray, G Storz, K Papenfort - Journal of bacteriology, 2022 - Am Soc Microbiol
In recent years, there has been increased appreciation that a whole category of proteins,
small proteins of around 50 amino acids or fewer in length, has been missed by annotation …

Bacterial pore-forming toxins

FR Ulhuq, G Mariano - Microbiology, 2022 - microbiologyresearch.org
Pore-forming toxins (PFTs) are widely distributed in both Gram-negative and Gram-positive
bacteria. PFTs can act as virulence factors that bacteria utilise in dissemination and host …

Wrangling actin assemblies: Actin ring dynamics during cell wound repair

J Hui, V Stjepić, M Nakamura, SM Parkhurst - Cells, 2022 - mdpi.com
To cope with continuous physiological and environmental stresses, cells of all sizes require
an effective wound repair process to seal breaches to their cortex. Once a wound is …

[HTML][HTML] Plant lectins: A new antimicrobial frontier

EHE Konozy, MEM Osman, AI Dirar… - Biomedicine & …, 2022 - Elsevier
Pathogenic bacteria, viruses, fungi, parasites, and other microbes constantly change to
ensure survival. Several pathogens have adopted strict and intricate strategies to fight …

Cytolysin A (ClyA): A Bacterial Virulence Factor with Potential Applications in Nanopore Technology, Vaccine Development, and Tumor Therapy

K Murase - Toxins, 2022 - mdpi.com
Cytolysin A (ClyA) is a pore-forming toxin that is produced by some bacteria from the
Enterobacteriaceae family. This review provides an overview of the current state of …

Endothelial ADAM10 utilization defines a molecular pathway of vascular injury in mice with bacterial sepsis

DN Alfano, MJ Miller… - The Journal of Clinical …, 2023 - Am Soc Clin Investig
The endothelium plays a critical role in the host response to infection and has been a focus
of investigation in sepsis. While it is appreciated that intravascular thrombus formation …

Challenges and approaches to studying pore-forming proteins

JT Benton, C Bayly-Jones - Biochemical Society Transactions, 2021 - portlandpress.com
Pore-forming proteins (PFPs) are a broad class of molecules that comprise various families,
structural folds, and assembly pathways. In nature, PFPs are most often deployed by their …

Pore-forming proteins: from pore assembly to structure by quantitative single-molecule imaging

E Margheritis, S Kappelhoff, K Cosentino - International Journal of …, 2023 - mdpi.com
Pore-forming proteins (PFPs) play a central role in many biological processes related to
infection, immunity, cancer, and neurodegeneration. A common feature of PFPs is their …

Evaluating Biofilm Inhibitory Potential in Fish Pathogen, Aeromonas hydrophila by Agricultural Waste Extracts and Assessment of Aerolysin Inhibitors Using In Silico …

M Arumugam, DB Manikandan, SK Marimuthu… - Antibiotics, 2023 - mdpi.com
Aeromonas hydrophila, an opportunistic bacteria, causes several devastating diseases in
humans and animals, particularly aquatic species. Antibiotics have been constrained by the …

Structural insight into Bacillus thuringiensis Sip1Ab reveals its similarity to ETX_MTX2 family beta‐pore‐forming toxin

Z Chen, Y Shi, D Wang, X Liu, X Jiao… - Pest Management …, 2023 - Wiley Online Library
BACKGROUND Microbially derived, protein‐based biopesticides are an important approach
for sustainable pest management. The secreted insecticidal proteins (Sips) produced by the …