Mathematical modeling of microbial community dynamics: a methodological review

HS Song, WR Cannon, AS Beliaev, A Konopka - Processes, 2014 - mdpi.com
Microorganisms in nature form diverse communities that dynamically change in structure
and function in response to environmental variations. As a complex adaptive system …

Dynamic models of metabolism: Review of the cybernetic approach

D Ramkrishna, HS Song - AIChE Journal, 2012 - Wiley Online Library
The cybernetic approach to metabolic modeling tracing its progress from its early beginnings
to its current state with regard to its relationship to other modeling approaches, applications …

Mapping the evolution of cybernetics: a bibliometric perspective

B Cibu, C Delcea, A Domenteanu, G Dumitrescu - Computers, 2023 - mdpi.com
In this study, we undertake a comprehensive bibliometric analysis of the cybernetics
research field. We compile a dataset of 4856 papers from the ISI Web of Science database …

DRUM: a new framework for metabolic modeling under non-balanced growth. Application to the carbon metabolism of unicellular microalgae

C Baroukh, R Muñoz-Tamayo, JP Steyer, O Bernard - PloS one, 2014 - journals.plos.org
Metabolic modeling is a powerful tool to understand, predict and optimize bioprocesses,
particularly when they imply intracellular molecules of interest. Unfortunately, the use of …

CODY enables quantitatively spatiotemporal predictions on in vivo gut microbial variability induced by diet intervention

J Geng, B Ji, G Li, F López-Isunza… - Proceedings of the …, 2021 - National Acad Sciences
Microbial variations in the human gut are harbored in temporal and spatial heterogeneity,
and quantitative prediction of spatiotemporal dynamic changes in the gut microbiota is …

[HTML][HTML] Modeling the metabolic dynamics at the genome-scale by optimized yield analysis

H Luo, P Li, B Ji, J Nielsen - Metabolic Engineering, 2023 - Elsevier
The hybrid cybernetic model (HCM) approach is a dynamic modeling framework that
integrates enzyme synthesis and activity regulation. It has been widely applied in …

Combining kinetic and constraint-based modelling to better understand metabolism dynamics

C Moulin, L Tournier, S Peres - Processes, 2021 - mdpi.com
To understand the phenotypic capabilities of organisms, it is useful to characterise cellular
metabolism through the analysis of its pathways. Dynamic mathematical modelling of …

A method of accounting for enzyme costs in flux balance analysis reveals alternative pathways and metabolite stores in an illuminated Arabidopsis leaf

CYM Cheung, RG Ratcliffe, LJ Sweetlove - Plant Physiology, 2015 - academic.oup.com
Flux balance analysis of plant metabolism is an established method for predicting metabolic
flux phenotypes and for exploring the way in which the plant metabolic network delivers …

Representing organic matter thermodynamics in biogeochemical reactions via substrate-explicit modeling

HS Song, JC Stegen, EB Graham, JY Lee… - Frontiers in …, 2020 - frontiersin.org
Predictive biogeochemical modeling requires data-model integration that enables explicit
representation of the sophisticated roles of microbial processes that transform substrates …

Cybernetic models based on lumped elementary modes accurately predict strain‐specific metabolic function

HS Song, D Ramkrishna - Biotechnology and Bioengineering, 2011 - Wiley Online Library
In a recent article, Song and Ramkrishna (Song and Ramkrishna [2010]. Biotechnol Bioeng
106 (2): 271–284) proposed a lumped hybrid cybernetic model (L‐HCM) towards extracting …