[HTML][HTML] Endothelial damage in sepsis: the importance of systems biology
J Fernández-Sarmiento, LJ Schlapbach… - Frontiers in …, 2022 - frontiersin.org
The early diagnosis and appropriate stratification of sepsis continues to be one of the most
important challenges in modern medicine. Single isolated biomarkers have not been …
important challenges in modern medicine. Single isolated biomarkers have not been …
[HTML][HTML] Neuroimmune regulation in sepsis-associated encephalopathy: the interaction between the brain and peripheral immunity
Y Liu, Y Yu, J Liu, W Liu, Y Cao, R Yan, Y Yao - Frontiers in neurology, 2022 - frontiersin.org
Sepsis-associated encephalopathy (SAE), the most popular cause of coma in the intensive
care unit (ICU), is the diffuse cerebral damage caused by the septic challenge. SAE is …
care unit (ICU), is the diffuse cerebral damage caused by the septic challenge. SAE is …
Multi-organ transcriptome dynamics in a mouse model of cecal ligation and puncture-induced polymicrobial sepsis
I Rumienczyk, M Kulecka, J Ostrowski… - Journal of …, 2021 - Taylor & Francis
Purpose During sepsis, an excessive inflammatory immune reaction contributes to multi-
organ dysfunction syndrome (MODS), a critical condition associated with high morbidity and …
organ dysfunction syndrome (MODS), a critical condition associated with high morbidity and …
Proteomic changes associated with racial background and sepsis survival outcomes
Intra-abdominal infection is a common cause of sepsis, and intra-abdominal sepsis leads
to∼ 156 000 US deaths annually. African American/Black adults have higher incidence and …
to∼ 156 000 US deaths annually. African American/Black adults have higher incidence and …
Succinate mediates inflammation-induced adrenocortical dysfunction
The hypothalamus-pituitary-adrenal (HPA) axis is activated in response to inflammation
leading to increased production of anti-inflammatory glucocorticoids by the adrenal cortex …
leading to increased production of anti-inflammatory glucocorticoids by the adrenal cortex …
Identification and validation of hub genes for predicting treatment targets and immune landscape in rheumatoid arthritis
X He, J Yin, M Yu, H Wang, J Qiu… - BioMed Research …, 2022 - Wiley Online Library
Background. Rheumatoid arthritis (RA) is recognized as a chronic inflammatory disease
featured by pathological synovial inflammation. Currently, the underlying pathophysiological …
featured by pathological synovial inflammation. Currently, the underlying pathophysiological …
Prolonged treatment with the synthetic glucocorticoid methylprednisolone affects adrenal steroidogenic function and response to inflammatory stress in the rat
F Spiga, Z Zhao, SL Lightman - Brain, Behavior, and Immunity, 2020 - Elsevier
Synthetic glucocorticoids are widely prescribed for the treatment of numerous inflammatory
and autoimmune diseases and they can also affect the way the adrenal gland produces …
and autoimmune diseases and they can also affect the way the adrenal gland produces …
[HTML][HTML] Omics of endothelial cell dysfunction in sepsis
JC Langston, MT Rossi, Q Yang, W Ohley… - Vascular …, 2022 - vb.bioscientifica.com
During sepsis, defined as life-threatening organ dysfunction due to dysregulated host
response to infection, systemic inflammation activates endothelial cells and initiates a …
response to infection, systemic inflammation activates endothelial cells and initiates a …
Aconitate decarboxylase 1 suppresses cerebral ischemia-reperfusion injury in mice
TM Vigil, RA Frieler, KAL Kilpatrick, MM Wang… - Experimental …, 2022 - Elsevier
Immunometabolic changes have been shown to be a key factor in determining the immune
cell response in disease models. The immunometabolite, itaconate, is produced by …
cell response in disease models. The immunometabolite, itaconate, is produced by …
[HTML][HTML] Triggering receptor expressed on myeloid Cells-2 (TREM2) inhibits steroidogenesis in adrenocortical cell by macrophage-derived exosomes in …
H Ye, Q Zhai, P Fang, S Yang, Y Sun, S Wu… - Molecular and Cellular …, 2021 - Elsevier
Purpose Endogenously produced glucocorticoids exhibit immunomodulating properties and
are of pivotal importance for sepsis outcome. Uncontrolled activation of the immune-adrenal …
are of pivotal importance for sepsis outcome. Uncontrolled activation of the immune-adrenal …