Lipid-based drug delivery systems in cancer therapy: what is available and what is yet to come

P Yingchoncharoen, DS Kalinowski… - Pharmacological …, 2016 - ASPET
Cancer is a leading cause of death in many countries around the world. However, the
efficacy of current standard treatments for a variety of cancers is suboptimal. First, most …

Advantages and challenges of the spray-drying technology for the production of pure drug particles and drug-loaded polymeric carriers

A Sosnik, KP Seremeta - Advances in colloid and interface science, 2015 - Elsevier
Spray-drying is a rapid, continuous, cost-effective, reproducible and scalable process for the
production of dry powders from a fluid material by atomization through an atomizer into a hot …

Cellular uptake, intracellular trafficking, and cytotoxicity of nanomaterials

F Zhao, Y Zhao, Y Liu, X Chang, C Chen, Y Zhao - small, 2011 - Wiley Online Library
The interactions of nanoparticles with the soft surfaces of biological systems like cells play
key roles in executing their biomedical functions and in toxicity. The discovery or design of …

PLGA particulate delivery systems for subunit vaccines: Linking particle properties to immunogenicity

AL Silva, PC Soema, B Slütter… - Human vaccines & …, 2016 - Taylor & Francis
Among the emerging subunit vaccines are recombinant protein-and synthetic peptide-based
vaccine formulations. However, proteins and peptides have a low intrinsic immunogenicity …

Nanoparticle targeting of anti-cancer drugs that alter intracellular signaling or influence the tumor microenvironment

M Kanapathipillai, A Brock, DE Ingber - Advanced drug delivery reviews, 2014 - Elsevier
Nanoparticle-based therapeutics are poised to become a leading delivery strategy for
cancer treatment because they potentially offer higher selectivity, reduced toxicity, longer …

Peptide/protein vaccine delivery system based on PLGA particles

M Allahyari, E Mohit - Human vaccines & immunotherapeutics, 2016 - Taylor & Francis
abstract Due to the excellent safety profile of poly (D, L-lactide-co-glycolide)(PLGA) particles
in human, and their biodegradability, many studies have focused on the application of PLGA …

Particulate formulations for the delivery of poly (I: C) as vaccine adjuvant

AM Hafner, B Corthésy, HP Merkle - Advanced drug delivery reviews, 2013 - Elsevier
Current research and development of antigens for vaccination often center on purified
recombinant proteins, viral subunits, synthetic oligopeptides or oligosaccharides, most of …

Immune system targeting by biodegradable nanoparticles for cancer vaccines

JM Silva, M Videira, R Gaspar, V Préat… - Journal of controlled …, 2013 - Elsevier
The concept of therapeutic cancer vaccines is based on the activation of the immune system
against tumor cells after the presentation of tumor antigens. Nanoparticles (NPs) have …

Nano-and micro-based inhaled drug delivery systems for targeting alveolar macrophages

WH Lee, CY Loo, D Traini… - Expert opinion on drug …, 2015 - Taylor & Francis
Introduction: Macrophages are the most versatile cells in the hematopoietic system and are
strategically distributed in tissues to fight pathogens or other foreign particles. In the lung …

Nanocarriers for intravenous injection—the long hard road to the market

M Wacker - International journal of pharmaceutics, 2013 - Elsevier
Nanodispersed drug delivery systems for the intravenous injection have successfully
overcome the hurdle of drug approval in the European Union and the United States …