Cell death is critical for the development and homeostasis of almost all multicellular
organisms. Moreover, its dysregulation leads to diverse disease states. Historically …

Antibodies targeting programmed cell death protein-1 (PD-1) or its ligand PD-L1 rescue T
cells from exhausted status and revive immune response against cancer cells. Based on the …

Molecular imaging has experienced enormous advancements in the areas of imaging
technology, imaging probe and contrast development, and data quality, as well as machine …

CD44, a complex transmembrane glycoprotein, exists in multiple molecular forms, including
the standard isoform CD44s and CD44 variant isoforms. CD44 participates in multiple …

Triple-negative breast cancer (TNBC), a highly aggressive subtype of breast cancer,
negatively expresses estrogen receptor, progesterone receptor, and the human epidermal …

Simple Summary Glioblastoma multiforme is one of the hardest-to-treat brain tumors, often
resistant to conventional treatments such as chemotherapy and radiation therapy. Despite …

Selective inhibitors of PARP1 and PARP2 (PARP1/2) are used to treat cancer patients with
deficiencies in the repair of DNA via homologous recombination. Here we provide a …

Simple Summary The progress of next-generation sequencing technologies has raised
huge expectations for precision-medicine therapy approaches in breast cancer and triple …

Poly (ADP-ribose) polymerase (PARP) 1 is an essential molecule in DNA damage response
by sensing DNA damage and docking DNA repair proteins on the damaged DNA site …

The principle of synthetic lethality, which refers to the loss of viability resulting from the
disruption of two genes, which, individually, do not cause lethality, has become an attractive …