Neuroinflammation has positive and negative effects. This review focuses on the roles of
macrophage in the PNS. Transection of PNS axons leads to degeneration and clearance of …

Peripheral nerves injuries result in paralysis, anesthesia and lack of autonomic control of the
affected body areas. After injury, axons distal to the lesion are disconnected from the …

Injuries to the peripheral nerves result in partial or total loss of motor, sensory and autonomic
functions conveyed by the lesioned nerves to the denervated segments of the body, due to …

Reactivation of a silent transcriptional program is a critical step in successful axon
regeneration following injury. Yet how such a program is unlocked after injury remains …

Chronic pain can occur after peripheral nerve injury, infection, or inflammation. Under such
neuropathic pain conditions, sensory processing in the affected body region becomes …

Neurotrophins (NTs) belong to a family of trophic factors that regulate the survival, growth
and programmed cell death of neurons. In mammals, there are four structurally and …

Target-derived NGF promotes the phenotypic maintenance of mature dorsal root ganglion
(DRG) nociceptive neurons. Here, we provide in vivo and in vitro evidence for the presence …

Nerve growth factor (NGF) was identified originally as a survival factor for sensory and
sympathetic neurons in the developing nervous system. In adults, NGF is not required for …

Calcitonin gene‐related peptide (CGRP) is a key mediator in primary headaches including
migraine. Animal models of meningeal nociception demonstrate both peripheral and central …

Damage to the nervous system can cause neuropathic pain, which is in general poorly
treated and involves mechanisms that are incompletely known. Currently available animal …