[HTML][HTML] Immunoglobulin G glycosylation in aging and diseases
Abstract The Immunoglobulin G (IgG) glycome is well known for its heterogeneity and shows
a significant degree of variation within populations. IgG glycome composition is influenced …
a significant degree of variation within populations. IgG glycome composition is influenced …
Human plasma protein N-glycosylation
F Clerc, KR Reiding, BC Jansen, GSM Kammeijer… - Glycoconjugate …, 2016 - Springer
Glycosylation is the most abundant and complex protein modification, and can have a
profound structural and functional effect on the conjugate. The oligosaccharide fraction is …
profound structural and functional effect on the conjugate. The oligosaccharide fraction is …
All around suboptimal health—a joint position paper of the Suboptimal Health Study Consortium and European Association for Predictive, Preventive and …
First two decades of the twenty-first century are characterised by epidemics of non-
communicable diseases such as many hundreds of millions of patients diagnosed with …
communicable diseases such as many hundreds of millions of patients diagnosed with …
[HTML][HTML] IgG glycans in health and disease: Prediction, intervention, prognosis, and therapy
S Shkunnikova, A Mijakovac, L Sironic, M Hanic… - Biotechnology …, 2023 - Elsevier
Immunoglobulin (IgG) glycosylation is a complex enzymatically controlled process, essential
for the structure and function of IgG. IgG glycome is relatively stable in the state of …
for the structure and function of IgG. IgG glycome is relatively stable in the state of …
Glycans are a novel biomarker of chronological and biological ages
Fine structural details of glycans attached to the conserved N-glycosylation site significantly
not only affect function of individual immunoglobulin G (IgG) molecules but also mediate …
not only affect function of individual immunoglobulin G (IgG) molecules but also mediate …
Life in the shadow of a dominant partner: the FVIII-VWF association and its clinical implications for hemophilia A
A normal hemostatic response to vascular injury requires both factor VIII (FVIII) and von
Willebrand factor (VWF). In plasma, VWF and FVIII normally circulate as a noncovalent …
Willebrand factor (VWF). In plasma, VWF and FVIII normally circulate as a noncovalent …
[HTML][HTML] Mechanisms of disease: The human N-glycome
Background The majority of human proteins are being modified by covalent attachment of
complex oligosaccharides—glycans. Both glycans and polypeptide parts of a protein …
complex oligosaccharides—glycans. Both glycans and polypeptide parts of a protein …
An overview of albumin and alpha-1-acid glycoprotein main characteristics: highlighting the roles of amino acids in binding kinetics and molecular interactions
M Bteich - Heliyon, 2019 - cell.com
Although Albumin (ALB) and alpha-1-acid glycoprotein (AGP) have distinctive structural and
functional characteristics, they both play a key role in binding a large variety of endogenous …
functional characteristics, they both play a key role in binding a large variety of endogenous …
Capillary electrophoresis separations of glycans
G Lu, CL Crihfield, S Gattu, LM Veltri… - Chemical …, 2018 - ACS Publications
Capillary electrophoresis has emerged as a powerful approach for carbohydrate analyses
since 2014. The method provides high resolution capable of separating carbohydrates by …
since 2014. The method provides high resolution capable of separating carbohydrates by …
Genomics meets glycomics—the first GWAS study of human N-glycome identifies HNF1α as a master regulator of plasma protein fucosylation
G Lauc, A Essafi, JE Huffman, C Hayward… - PLoS …, 2010 - journals.plos.org
Over half of all proteins are glycosylated, and alterations in glycosylation have been
observed in numerous physiological and pathological processes. Attached glycans …
observed in numerous physiological and pathological processes. Attached glycans …