Idiopathic pulmonary fibrosis: Disease mechanisms and drug development
P Spagnolo, JA Kropski, MG Jones, JS Lee… - Pharmacology & …, 2021 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease of unknown cause
characterized by relentless scarring of the lung parenchyma leading to reduced quality of life …
characterized by relentless scarring of the lung parenchyma leading to reduced quality of life …
Idiopathic pulmonary fibrosis
FJ Martinez, HR Collard, A Pardo, G Raghu… - Nature reviews Disease …, 2017 - nature.com
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease characterized by
progressive lung scarring and the histological picture of usual interstitial pneumonia (UIP). It …
progressive lung scarring and the histological picture of usual interstitial pneumonia (UIP). It …
Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a fatal and incurable form of interstitial lung disease in
which persistent injury results in scar tissue formation. As fibrosis thickens, the lung tissue …
which persistent injury results in scar tissue formation. As fibrosis thickens, the lung tissue …
MSC based therapies—new perspectives for the injured lung
J Behnke, S Kremer, T Shahzad, CM Chao… - Journal of clinical …, 2020 - mdpi.com
Chronic lung diseases pose a tremendous global burden. At least one in four people suffer
from severe pulmonary sequelae over the course of a lifetime. Despite substantial …
from severe pulmonary sequelae over the course of a lifetime. Despite substantial …
New insights into pathomechanisms and treatment possibilities for lung silicosis
J Adamcakova, D Mokra - International journal of molecular sciences, 2021 - mdpi.com
Inhalation of silica particles is an environmental and occupational cause of silicosis, a type
of pneumoconiosis. Development of the lung silicosis is a unique process in which the …
of pneumoconiosis. Development of the lung silicosis is a unique process in which the …
Allogeneic human mesenchymal stem cells in patients with idiopathic pulmonary fibrosis via intravenous delivery (AETHER): a phase I safety clinical trial
MK Glassberg, J Minkiewicz, RL Toonkel, ES Simonet… - Chest, 2017 - Elsevier
Background Despite Food and Drug Administration approval of 2 new drugs for idiopathic
pulmonary fibrosis (IPF), curative therapies remain elusive and mortality remains high …
pulmonary fibrosis (IPF), curative therapies remain elusive and mortality remains high …
A phase 1b study of placenta‐derived mesenchymal stromal cells in patients with idiopathic pulmonary fibrosis
DC Chambers, D Enever, N Ilic, L Sparks… - …, 2014 - Wiley Online Library
Background and objective Idiopathic pulmonary fibrosis (IPF) is a degenerative disease
characterized by fibrosis following failed epithelial repair. Mesenchymal stromal cells (MSC) …
characterized by fibrosis following failed epithelial repair. Mesenchymal stromal cells (MSC) …
Clinical application of mesenchymal stem cell-derived extracellular vesicle-based therapeutics for inflammatory lung diseases
It is currently thought that extracellular vesicles (EVs), such as exosomes and microvesicles,
play an important autocrine/paracrine role in intercellular communication. EVs package …
play an important autocrine/paracrine role in intercellular communication. EVs package …
Interstitial lung disease
KM Antoniou, GA Margaritopoulos… - European …, 2014 - Eur Respiratory Soc
Interstitial lung diseases are a group of diffuse parenchymal lung disorders associated with
substantial morbidity and mortality. Knowledge achieved in recent years has resulted in the …
substantial morbidity and mortality. Knowledge achieved in recent years has resulted in the …
Pulmonary fibrosis from molecular mechanisms to therapeutic interventions: lessons from post-COVID-19 patients
C Giacomelli, R Piccarducci, L Marchetti… - Biochemical …, 2021 - Elsevier
Pulmonary fibrosis (PF) is characterised by several grades of chronic inflammation and
collagen deposition in the interalveolar space and is a hallmark of interstitial lung diseases …
collagen deposition in the interalveolar space and is a hallmark of interstitial lung diseases …