Artificial biocatalytic linear cascades for preparation of organic molecules

JH Schrittwieser, S Velikogne, M Hall… - Chemical …, 2018 - ACS Publications
The review compiles artificial cascades involving enzymes with a focus on the last 10 years.
A cascade is defined as the combination of at least two reaction steps in a single reaction …

Alkane oxidation: methane monooxygenases, related enzymes, and their biomimetics

VCC Wang, S Maji, PPY Chen, HK Lee, SSF Yu… - Chemical …, 2017 - ACS Publications
Methane monooxygenases (MMOs) mediate the facile conversion of methane into methanol
in methanotrophic bacteria with high efficiency under ambient conditions. Because the …

Scalable biocatalytic C–H oxyfunctionalization reactions

S Chakrabarty, Y Wang, JC Perkins… - Chemical Society …, 2020 - pubs.rsc.org
Catalytic C–H oxyfunctionalization reactions have garnered significant attention in recent
years with their ability to streamline synthetic routes toward complex molecules …

Biocatalysis for the synthesis of pharmaceuticals and pharmaceutical intermediates

H Sun, H Zhang, EL Ang, H Zhao - Bioorganic & medicinal chemistry, 2018 - Elsevier
Biocatalysis has been increasingly used for pharmaceutical synthesis in an effort to make
manufacturing processes greener and more sustainable. Biocatalysts that possess excellent …

Cytochrome P450 monooxygenases in biotechnology and synthetic biology

VB Urlacher, M Girhard - Trends in biotechnology, 2019 - cell.com
Cytochromes P450 (P450 or CYP) are heme-containing enzymes that catalyze the
introduction of one atom of molecular oxygen into nonactivated C–H bonds, often in a regio …

[HTML][HTML] Enzymes revolutionize the bioproduction of value-added compounds: From enzyme discovery to special applications

B Wiltschi, T Cernava, A Dennig, MG Casas… - Biotechnology …, 2020 - Elsevier
Competitive sustainable production in industry demands new and better biocatalysts,
optimized bioprocesses and cost-effective product recovery. Our review sheds light on the …

Building bridges: Biocatalytic C–C-bond formation toward multifunctional products

NG Schmidt, E Eger, W Kroutil - ACS catalysis, 2016 - ACS Publications
Carbon–carbon bond formation is the key reaction for organic synthesis to construct the
carbon framework of organic molecules. The review gives a selection of biocatalytic C–C …

Homogeneous oxygenase catalysis

Y Liang, J Wei, X Qiu, N Jiao - Chemical reviews, 2018 - ACS Publications
Oxygenases-catalyzed reductive activation of molecular oxygen and incorporation of O
atoms into an organic molecule is undoubtedly one of the most attractive research areas …

Enzymatic Oxy‐and Amino‐Functionalization in Biocatalytic Cascade Synthesis: Recent Advances and Future Perspectives

E Grandi, F Feyza Özgen, S Schmidt… - Angewandte …, 2023 - Wiley Online Library
Biocatalytic cascades are a powerful tool for building complex molecules containing oxygen
and nitrogen functionalities. Moreover, the combination of multiple enzymes in one pot offers …

A roadmap for biocatalysis–functional and spatial orchestration of enzyme cascades

C Schmidt‐Dannert… - Microbial biotechnology, 2016 - Wiley Online Library
Advances in biological engineering and systems biology have provided new approaches
and tools for the industrialization of biology. In the next decade, advanced biocatalytic …