CRISPR/Cas9 approaches are revolutionizing our ability to perform functional genomics
across a wide range of organisms, including the Plasmodium parasites that cause malaria …

The∼ 30 Mb genomes of the Plasmodium parasites that cause malaria each encode∼
5000 genes, but the functions of the majority remain unknown. This is due to a paucity of …

Faithful chromosome segregation of 8 duplicated haploid genomes into 8 daughter gametes
is essential for male gametogenesis and mosquito transmission of Plasmodium …

Malaria is caused by infection with Plasmodium parasites and is a major public health
concern. The CRISPR/Cas9 system is a promising technology, but still has technical …

Gametocytes differentiation to gametes (gametogenesis) within mosquitos is essential for
malaria parasite transmission. Both reduction in temperature and mosquito-derived XA or …

Malaria remains a major global health issue, affecting millions and killing hundreds of
thousands of people annually. Efforts to break the transmission cycle of the causal …

Malaria as vector-borne disease remains important health concern with over 200 million
cases globally. Novel antimalarial medicines and more effective vaccines must be …

The CRISPR/Cas9 system is a powerful genetic engineering technology for Plasmodium
falciparum. We here report further improvement of the CRISPR/Cas9 system by combining …

Studies of molecular mechanisms and related gene functions have long been restricted by
limited genome editing technologies in malaria parasites. Recently, a simple and effective …

The ambitious goal of malaria elimination requires an in-depth understanding of the
parasite's biology to counter the growing threat of antimalarial resistance and immune …