Merged magnetic resonance and light sheet microscopy of the whole mouse brain
We have developed workflows to align 3D magnetic resonance histology (MRH) of the
mouse brain with light sheet microscopy (LSM) and 3D delineations of the same specimen …
mouse brain with light sheet microscopy (LSM) and 3D delineations of the same specimen …
[HTML][HTML] Precise cerebral vascular atlas in stereotaxic coordinates of whole mouse brain
Understanding amazingly complex brain functions and pathologies requires a complete
cerebral vascular atlas in stereotaxic coordinates. Making a precise atlas for cerebral …
cerebral vascular atlas in stereotaxic coordinates. Making a precise atlas for cerebral …
Staining and embedding the whole mouse brain for electron microscopy
The development of methods for imaging large contiguous volumes with the electron
microscope could allow the complete mapping of a whole mouse brain at the single-axon …
microscope could allow the complete mapping of a whole mouse brain at the single-axon …
[HTML][HTML] Mapping the connectome: multi-level analysis of brain connectivity
Figure 1| From multi-modal connectivity data to integrated connectomes. Image panels
illustrating recent progress, selected and modified from contributions to the Research Topic …
illustrating recent progress, selected and modified from contributions to the Research Topic …
Possum—a framework for three-dimensional reconstruction of brain images from serial sections
Techniques based on imaging serial sections of brain tissue provide insight into brain
structure and function. However, to compare or combine them with results from three …
structure and function. However, to compare or combine them with results from three …
Modelling the brain: Elementary components to explain ensemble functions
E D'Angelo, CG Wheeler-Kingshott - La Rivista del Nuovo Cimento, 2017 - Springer
The brain is organized on multiple levels. The lowest meaningful one pertains to the
molecular realm, followed by subcellular structures like the synapses, by cells like the …
molecular realm, followed by subcellular structures like the synapses, by cells like the …
Image-guided, laser-based fabrication of vascular-derived microfluidic networks
KA Heintz, D Mayerich, JH Slater - JoVE (Journal of Visualized …, 2017 - jove.com
This detailed protocol outlines the implementation of image-guided, laser-based hydrogel
degradation for the fabrication of vascular-derived microfluidic networks embedded in …
degradation for the fabrication of vascular-derived microfluidic networks embedded in …
Mapping the full vascular network in the mouse brain at submicrometer resolution
Mapping the microvascular networks in the brain can lead to significant scientific and clinical
insights. We developed a serial sectioning microscopy technique called the Knife-Edge …
insights. We developed a serial sectioning microscopy technique called the Knife-Edge …
Knife-edge scanning microscopy for bright-field multi-cubic centimeter analysis of microvasculature
MJ Pesavento, C Miller, K Pelton, M Maloof… - Microscopy …, 2017 - academic.oup.com
Serial section microscopy has proven to be a powerful tool in examining the 3-dimensional
(3D) nature of tissue; however, it is limited by the size of tissue samples that can be used …
(3D) nature of tissue; however, it is limited by the size of tissue samples that can be used …
Conneconomics: the economics of dense, large-scale, high-resolution neural connectomics
We analyze the scaling and cost-performance characteristics of current and projected
connectomics approaches, with reference to the potential implications of recent advances in …
connectomics approaches, with reference to the potential implications of recent advances in …