With computation models playing an ever increasing role in the advancement of science, it is
important that researchers understand what it means to model something; recognize the …

Living tissues are active, multifunctional materials capable of generating, sensing,
withstanding and responding to mechanical stress. These capabilities enable tissues to …

Growth is central to plant morphogenesis. Plant cells are encased in rigid cell walls, and
they must overcome physical confinement to grow to specific sizes and shapes. Cell wall …

During animal development, cell-fate-specific changes in gene expression can modify the
material properties of a tissue and drive tissue morphogenesis. While mechanistic insights …

Development, homeostasis and regeneration of tissues result from a complex combination
of genetics and mechanics, and progresses in the former have been quicker than in the …

Understanding the mechanisms regulating development requires a quantitative
characterization of cell divisions, rearrangements, cell size and shape changes, and …

Cell-generated forces produce a variety of tissue movements and tissue shape changes.
The cytoskeletal elements that underlie these dynamics act at cell–cell and cell–ECM …

Communities of epithelial cells communicate through intercellular interactions, allowing
them to coordinate their motility, which plays a key role in homeostasis, morphogenesis and …

Cell packing—the spatial arrangement of cells—determines the shapes of organs. Recently,
investigations of organ development in a variety of model organisms have uncovered …

Mechanical forces shape biological tissues. They are the effectors of the developmental
programs that orchestrate morphogenesis. A lot of effort has been devoted to understanding …