Membrane sphingolipids are metabolized to sphingosine-1-phosphate (S1P), a bioactive
lipid mediator that regulates many processes in vertebrate development, physiology, and …

The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

In 2005, the American Thoracic Society marks its 100th year of existence. For over a third of
this span, since 1967, clinicians and investigators have struggled with a common, often …

Abstract Sphingosine 1-phosphate (S1P) is a biologically active lysophospholipid that
transmits signals through a family of G-protein-coupled receptors to control cellular …

The role of platelets in hemostasis is to produce a plug to arrest bleeding. During
thrombocytopenia, spontaneous bleeding is seen in some patients but not in others; the …

Sphingolipids, ubiquitous membrane lipids in eukaryotes, carry out a myriad of critical
cellular functions. The past two decades have seen significant advances in sphingolipid …

Although the pathogenic and genetic basis of acute lung injury (ALI) remains incompletely
understood, the identification of novel ALI biomarkers holds promise for unique insights …

Abstract Sphingosine 1-phosphate (S1P, 1) regulates vascular barrier and lymphoid
development, as well as lymphocyte egress from lymphoid organs, by activating high-affinity …

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease of unknown etiology
characterized by distorted distal lung architecture, inflammation, and fibrosis. The molecular …

C5a is the paramount proinflammatory mediator of the complement cascade, and has been
previously thought to act only through a single, G‐protein‐coupled, C5a receptor (C5aR; …