Background. Extracellular vesicles (EVs) play an essential role in the communication
between cells and transport of diagnostically significant molecules. A wide diversity of …

Exosomes are a subset of extracellular vesicles that carry specific combinations of proteins,
nucleic acids, metabolites, and lipids. Mounting evidence suggests that exosomes …

Extracellular vesicles (EVs) are becoming promising tools for clinical application, either as
sources of disease-specific molecular signatures for the unraveling of disease …

The re-discovery of exosomes as intercellular messengers with high potential for diagnostic
and therapeutic utility has led to them becoming a popular topic of research in recent years …

The persistence of cholesterol-engorged macrophages (foam cells) in the artery wall fuels
the development of atherosclerosis. However, the mechanism that regulates the formation of …

There is growing demand for novel biomarkers that detect early stage disease as well as
monitor clinical management and therapeutic strategies. Exosome analysis could provide …

Phosphorylation of the pseudokinase mixed lineage kinase domain-like protein (MLKL) by
the protein kinase RIPK3 targets MLKL to the cell membrane, where it triggers necroptotic …

The sensing of nucleic acids by receptors of the innate immune system is a key component
of antimicrobial immunity. RNA: DNA hybrids, as essential intracellular replication …

Intracellular galectins are carbohydrate-binding proteins capable of sensing and repairing
damaged lysosomes. As in the physiological conditions glycosylated moieties are mostly in …

Emerging studies implicate Tau as an essential mediator of neuronal atrophy and cognitive
impairment in Alzheimer's disease (AD), yet the factors that precipitate Tau dysfunction in AD …