Purpose: The increasing global risk of nuclear and radiological accidents or attacks has
driven renewed research interest in developing medical countermeasures to potentially …

Introduction: There is a limited array of currently available medicinals that are useful for
either the prevention, mitigation or treatment of bodily injuries arising from ionizing radiation …

The range of radiation threats we face today includes everything from individual radiation
exposures to mass casualties resulting from a terrorist incident, and many of these exposure …

One of the greatest national security threats to the United States is the detonation of an
improvised nuclear device or a radiological dispersal device in a heavily populated area. As …

Leukocyte growth factors (LGF), such as filgrastim, pegfilgrastim and sargramostim, have
been used to mitigate the hematologic symptoms of acute radiation syndrome (ARS) after …

Introduction: Despite significant scientific advances over the past 60 years towards the
development of a safe, nontoxic and effective radiation countermeasure for the acute …

Background Compared to radiation injury alone (RI), radiation injury combined wound (CI)
further enhances acute radiation syndrome and subsequently mortality. We previously …

Introduction: The global threat of a chemical, biological, radiological, or nuclear (CBRN)
disaster is an important priority for all government agencies involved in domestic security …

Purpose Preparedness for medical responses to major radiation accidents and the
increasing threat of nuclear warfare worldwide necessitates an understanding of the …

Radiation-combined injury (RCI) augments the risk of morbidity and mortality when
compared to radiation injury (RI) alone. No FDA-approved medical countermeasures …