Recently, the incidence of brain diseases, such as central nervous system degenerative
diseases, brain tumors, and cerebrovascular diseases, has increased. However, the blood …

Peptide–drug conjugates (PDCs) have emerged as a promising class of targeted
therapeutics with substantial pharmaceutical advantages and market potentials, which is a …

Chemotherapy is still one of the main therapeutic approaches in cancer therapy.
Nevertheless, its poor selectivity causes severe toxic side effects that, together with the …

Malignant melanoma is one of the most aggressive and resistant tumor types, with high
metastatic properties. Because of the lack of suitable chemotherapeutic agents for treatment …

Neuroinfections are difficult and time-consuming to treat. The main bottleneck in therapy is
drugs' inability to enter the central nervous system (CNS) via the blood-brain barrier (BBB) …

Transporting therapeutics through the blood-brain barrier (BBB) is a demanding/ambitious
challenge in treating brain tumors. The BBB is semipermeable; therefore, most active …