Obesity, inflammation, and immune system in osteoarthritis

U Nedunchezhiyan, I Varughese, ARJ Sun… - Frontiers in …, 2022 - frontiersin.org
Obesity remains the most important risk factor for the incidence and progression of
osteoarthritis (OA). The leading cause of OA was believed to be overloading the joints due to …

[HTML][HTML] Epidemiology of osteoarthritis

KD Allen, LM Thoma, YM Golightly - Osteoarthritis and cartilage, 2022 - Elsevier
Objective To summarize the current state of the evidence regarding osteoarthritis (OA)
prevalence, incidence and risk factors at the person-level and joint-level. Design This was a …

2019 American College of Rheumatology/Arthritis Foundation guideline for the management of osteoarthritis of the hand, hip, and knee

SL Kolasinski, T Neogi, MC Hochberg… - Arthritis & …, 2020 - Wiley Online Library
Objective To develop an evidence‐based guideline for the comprehensive management of
osteoarthritis (OA) as a collaboration between the American College of Rheumatology …

Knee osteoarthritis: a review of pathogenesis and state-of-the-art non-operative therapeutic considerations

D Primorac, V Molnar, E Rod, Ž Jeleč, F Čukelj… - Genes, 2020 - mdpi.com
Being the most common musculoskeletal progressive condition, osteoarthritis is an
interesting target for research. It is estimated that the prevalence of knee osteoarthritis (OA) …

Evaluation and treatment of knee pain: a review

V Duong, WM Oo, C Ding, AG Culvenor, DJ Hunter - Jama, 2023 - jamanetwork.com
Importance Approximately 5% of all primary care visits in adults are related to knee pain.
Osteoarthritis (OA), patellofemoral pain, and meniscal tears are among the most common …

Chondrocyte dedifferentiation and osteoarthritis (OA)

E Charlier, C Deroyer, F Ciregia, O Malaise… - Biochemical …, 2019 - Elsevier
Osteoarthritis (OA) is a degenerative joint disease characterized by progressive cartilage
degradation but also synovial membrane inflammation, osteophyte formation and …

The development of disease-modifying therapies for osteoarthritis (DMOADs): the evidence to date

WM Oo, C Little, V Duong, DJ Hunter - Drug Design, Development …, 2021 - Taylor & Francis
Osteoarthritis (OA) is a complex heterogeneous articular disease with multiple joint tissue
involvement of varying severity and no regulatory-agency-approved disease-modifying …

Update on the epidemiology, risk factors and disease outcomes of osteoarthritis

TW O'Neill, PS McCabe, J McBeth - Best practice & research Clinical …, 2018 - Elsevier
Osteoarthritis (OA) is the most frequent form of arthritis and a leading cause of pain and
disability worldwide. OA can affect any synovial joint, although the hip, knee, hand, foot and …

The burden of osteoarthritis in older adults

GA Hawker, LK King - Clinics in geriatric medicine, 2022 - geriatric.theclinics.com
Osteoarthritis (OA) is a serious disease. The most common form of arthritis, 1 OA typically
affects the hips, knees, hands, feet, and spine, and multijoint involvement is common. 2 OA …

BMP signalling in skeletal development, disease and repair

VS Salazar, LW Gamer, V Rosen - Nature Reviews Endocrinology, 2016 - nature.com
Since the identification in 1988 of bone morphogenetic protein 2 (BMP2) as a potent inducer
of bone and cartilage formation, BMP superfamily signalling has become one of the most …