Errors occurring during DNA replication can result in inaccurate replication, incomplete
replication, or re-replication, resulting in genome instability that can lead to diseases such as …

The 3D organization of mammalian chromatin was described more than 30 years ago by
visualizing sites of DNA synthesis at different times during the S phase of the cell cycle …

Somatic mutations in human cancers show unevenness in genomic distribution that
correlate with aspects of genome structure and function. These mutations are, however …

Whole genome sequencing of human tumours has revealed distinct patterns of mutation that
hint at the causative origins of cancer. Experimental investigations of the mutations and …

In late mitosis and early G1, Mcm2–7 complexes are loaded onto DNA to license replication
origins for use in the upcoming S phase. However, the amount of Mcm2–7 loaded is in …

The minichromosome maintenance (or MCM) protein family is composed of six related
proteins that are conserved in all eukaryotes. They were first identified by genetic screens in …

DNA replication in mammals is regulated via the coordinate firing of clusters of replicons that
duplicate megabase-sized chromosome segments at specific times during S-phase …

Background DNA replication in mammalian cells occurs in a defined temporal order during
S phase, known as the replication timing (RT) programme. Replication timing is …

Antibiotics represent a frequently employed therapeutic modality for the management of
bacterial infections across diverse domains, including human health, agriculture, livestock …

In late mitosis and early G1, replication origins are licensed for subsequent use by loading
complexes of the minichromosome maintenance proteins 2–7 (Mcm2–7). The number of …