Clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 9
(Cas9) is a precise genome manipulating technology that can be programmed to induce …

DNA double-strand breaks (DSBs) are cytotoxic lesions that can result in mutagenic events
or cell death if left unrepaired or repaired inappropriately. Cells use two major pathways for …

Alternative end-joining (a-EJ) pathways, which repair DNA double-strand breaks (DSBs),
are initiated by end resection that generates 3′ single strands. This reaction is shared, at …

The DNA double-strand break repair complex Mre11-Rad50-Nbs1 (MRN) detects and
nucleolytically processes DNA ends, activates the ATM kinase, and tethers DNA at break …

Homologous recombination (HR) is required for accurate chromosome segregation during
the first meiotic division and constitutes a key repair and tolerance pathway for complex DNA …

MicroRNAs (miRNAs), which function as regulators of gene expression in eukaryotes, are
processed from larger transcripts by sequential action of nuclear and cytoplasmic …

Homology-dependent exchange of genetic information between DNA molecules has a
profound impact on the maintenance of genome integrity by facilitating error-free DNA …

The maintenance of genome stability depends on the DNA damage response (DDR), which
is a functional network comprising signal transduction, cell cycle regulation and DNA repair …

Chromothripsis, the shattering and imperfect reassembly of one (or a few) chromosome (s),
is an ubiquitous mutational process generating localized and complex chromosomal …

Genome integrity is constantly monitored by sophisticated cellular networks, collectively
termed the DNA damage response (DDR). A common feature of DDR proteins is their …