The action of proteases can be controlled by several mechanisms, including regulation
through gene expression; post-translational modifications, such as glycosylation; zymogen …

Human plasma kallikrein (PKa) is obtained by activating its precursor, prekallikrein (PK),
historically named the Fletcher factor. Human PKa and tissue kallikreins are serine …

Six α-amylase/subtilisin inhibitor genes (MnASIs) were identified from mulberry (Morus
notabilis). In this study, bioinformatics and expression pattern analysis of six MnASIs were …

Background. Elastase mediates important oxidative actions during the development of
chronic obstructive pulmonary disease (COPD). However, few resources for the inhibition of …

Plant proteinase/protease inhibitors (PIs) have therapeutic potential besides their role in
regulating endogenous protease activity in several physiological processes. They exert their …

Metastasis, the primary cause of death from malignant tumors, is facilitated by multiple
protease-mediated processes. Thus, effort has been invested in the development of …

Functionality of the fibrinolytic system is based on activity of its central enzyme, plasmin,
responsible for the removal of fibrin clots. Besides the hemostasis, fibrinolytic proteins are …

Histidine acid phosphatases (HAPs) utilize a nucleophilic histidine residue to catalyze the
transfer of a phosphoryl group from phosphomonoesters to water. HAPs function as protein …

Structures of BbKI, a recombinant Kunitz-type serine protease inhibitor from Bauhinia
bauhinioides, complexed with human kallikrein 4 (KLK4) were determined at medium-to …

Structures of a recombinant Kunitz-type serine protease inhibitor from Bauhinia
bauhinioides (BbKI) complexed with bovine trypsin were determined in two crystal forms …