The Parkinson progression marker initiative (PPMI)
K Marek, D Jennings, S Lasch, A Siderowf… - Progress in …, 2011 - Elsevier
The Parkinson Progression Marker Initiative (PPMI) is a comprehensive observational,
international, multi-center study designed to identify PD progression biomarkers both to …
international, multi-center study designed to identify PD progression biomarkers both to …
Dynamic whole-body PET imaging: principles, potentials and applications
Purpose In this article, we discuss dynamic whole-body (DWB) positron emission
tomography (PET) as an imaging tool with significant clinical potential, in relation to …
tomography (PET) as an imaging tool with significant clinical potential, in relation to …
The scientific and clinical basis for the treatment of Parkinson disease (2009)
CW Olanow, MB Stern, K Sethi - Neurology, 2009 - AAN Enterprises
Parkinson disease (PD) is an age-related neurodegenerative disorder that affects as many
as 1–2% of persons aged 60 years and older. With the aging of the population, the …
as 1–2% of persons aged 60 years and older. With the aging of the population, the …
A double‐blind, placebo‐controlled study to assess the mitochondria‐targeted antioxidant MitoQ as a disease‐modifying therapy in Parkinson's disease
BJ Snow, FL Rolfe, MM Lockhart… - Movement …, 2010 - Wiley Online Library
Multiple lines of evidence point to mitochondrial oxidative stress as a potential pathogenic
cause for Parkinson's disease (PD). MitoQ is a powerful mitochondrial antioxidant. It is …
cause for Parkinson's disease (PD). MitoQ is a powerful mitochondrial antioxidant. It is …
Priorities in Parkinson's disease research
WG Meissner, M Frasier, T Gasser, CG Goetz… - Nature reviews Drug …, 2011 - nature.com
The loss of dopaminergic neurons in the substantia nigra pars compacta leads to the
characteristic motor symptoms of Parkinson's disease: bradykinesia, rigidity and resting …
characteristic motor symptoms of Parkinson's disease: bradykinesia, rigidity and resting …
Neuroprotective and therapeutic strategies against Parkinson's disease: recent perspectives
S Sarkar, J Raymick, S Imam - International journal of molecular sciences, 2016 - mdpi.com
Parkinsonism is a progressive motor disease that affects 1.5 million Americans and is the
second most common neurodegenerative disease after Alzheimer's. Typical …
second most common neurodegenerative disease after Alzheimer's. Typical …
Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2–neurturin) to patients with idiopathic Parkinson's disease: an open …
WJ Marks, JL Ostrem, L Verhagen, PA Starr… - The Lancet …, 2008 - thelancet.com
Background There is an urgent need for therapies that slow or reverse the progression of
Parkinson's disease (PD). Neurotrophic factors can improve the function of degenerating …
Parkinson's disease (PD). Neurotrophic factors can improve the function of degenerating …
High-resolution diffusion tensor imaging in the substantia nigra of de novo Parkinson disease
Background: In the midbrain of patients with Parkinson disease (PD), there is a selective
loss of dopaminergic neurons in the ventrolateral and caudal substantia nigra (SN). In a …
loss of dopaminergic neurons in the ventrolateral and caudal substantia nigra (SN). In a …
Changes in network activity with the progression of Parkinson's disease
C Huang, C Tang, A Feigin, M Lesser, Y Ma, M Pourfar… - Brain, 2007 - academic.oup.com
Parkinson's disease (PD) is associated with abnormal activity in spatially distributed neural
systems mediating the motor and cognitive manifestations of this disorder. Metabolic PET …
systems mediating the motor and cognitive manifestations of this disorder. Metabolic PET …
Abnormal metabolic network activity in Parkinson's disease: test—retest reproducibility
Y Ma, C Tang, PG Spetsieris… - Journal of Cerebral …, 2007 - journals.sagepub.com
Parkinson's disease (PD) is associated with an abnormal pattern of regional brain function.
The expression of this PD-related covariance pattern (PDRP) has been used to assess …
The expression of this PD-related covariance pattern (PDRP) has been used to assess …