Food as medicine: targeting the uraemic phenotype in chronic kidney disease
D Mafra, NA Borges, B Lindholm, PG Shiels… - Nature Reviews …, 2021 - nature.com
The observation that unhealthy diets (those that are low in whole grains, fruits and
vegetables, and high in sugar, salt, saturated fat and ultra-processed foods) are a major risk …
vegetables, and high in sugar, salt, saturated fat and ultra-processed foods) are a major risk …
[HTML][HTML] Mitochondrial (dys) function and insulin resistance: from pathophysiological molecular mechanisms to the impact of diet
Mitochondrial dysfunction has been implicated in the pathogenesis of insulin resistance, the
hallmark of type 2 diabetes mellitus (T2DM). However, the cause-effect relationship remains …
hallmark of type 2 diabetes mellitus (T2DM). However, the cause-effect relationship remains …
The role of ceramides in insulin resistance
E Sokolowska, A Blachnio-Zabielska - Frontiers in Endocrinology, 2019 - frontiersin.org
Resistance to insulin is a pathophysiological state related to the decreased response of
peripheral tissues to the insulin action, hyperinsulinemia and raised blood glucose levels …
peripheral tissues to the insulin action, hyperinsulinemia and raised blood glucose levels …
Adipose tissue macrophage populations and inflammation are associated with systemic inflammation and insulin resistance in obesity
Obesity is accompanied by numerous systemic and tissue-specific derangements, including
systemic inflammation, insulin resistance, and mitochondrial abnormalities in skeletal …
systemic inflammation, insulin resistance, and mitochondrial abnormalities in skeletal …
Omega-3 fatty acids and insulin resistance: focus on the regulation of mitochondria and endoplasmic reticulum stress
M Lepretti, S Martucciello, MA Burgos Aceves, R Putti… - Nutrients, 2018 - mdpi.com
Mitochondrial dysfunction and endoplasmic reticulum (ER) stress have been suggested to
play a key role in insulin resistance development. Reactive oxygen species (ROS) …
play a key role in insulin resistance development. Reactive oxygen species (ROS) …
Moderate aerobic exercise training ameliorates impairment of mitochondrial function and dynamics in skeletal muscle of high‐fat diet‐induced obese mice
The purpose of this study is to determine whether moderate aerobic exercise training
improves high‐fat diet‐induced alterations in mitochondrial function and structure in the …
improves high‐fat diet‐induced alterations in mitochondrial function and structure in the …
Altered mitochondrial function in insulin-deficient and insulin-resistant states
GN Ruegsegger, AL Creo, TM Cortes… - The Journal of …, 2018 - Am Soc Clin Investig
Diabetes profoundly alters fuel metabolism; both insulin deficiency and insulin resistance
are characterized by inefficient mitochondrial coupling and excessive production of reactive …
are characterized by inefficient mitochondrial coupling and excessive production of reactive …
Lipid modulation of skeletal muscle mass and function
C Lipina, HS Hundal - Journal of cachexia, sarcopenia and …, 2017 - Wiley Online Library
Loss of skeletal muscle mass is a characteristic feature of various pathologies including
cancer, diabetes, and obesity, as well as being a general feature of ageing. However, the …
cancer, diabetes, and obesity, as well as being a general feature of ageing. However, the …
Omega-3 fatty acids and skeletal muscle health
Skeletal muscle is a plastic tissue capable of adapting and mal-adapting to physical activity
and diet. The response of skeletal muscle to adaptive stimuli, such as exercise, can be …
and diet. The response of skeletal muscle to adaptive stimuli, such as exercise, can be …
[HTML][HTML] Influence of omega-3 fatty acids on skeletal muscle protein metabolism and mitochondrial bioenergetics in older adults
Omega-3 polyunsaturated fatty acids (n3-PUFA) are recognized for their anti-inflammatory
effects and may be beneficial in the context of sarcopenia. We determined the influence of …
effects and may be beneficial in the context of sarcopenia. We determined the influence of …