Molecular pathways: understanding the role of Rad52 in homologous recombination for therapeutic advancement
BH Lok, SN Powell - Clinical cancer research, 2012 - AACR
The Rad52 protein was largely ignored in humans and other mammals when the mouse
knockout revealed a largely “no-effect” phenotype. However, using synthetic lethal …
knockout revealed a largely “no-effect” phenotype. However, using synthetic lethal …
Reappearance from obscurity: mammalian Rad52 in homologous recombination
K Hanamshet, OM Mazina, AV Mazin - Genes, 2016 - mdpi.com
Homologous recombination (HR) plays an important role in maintaining genomic integrity. It
is responsible for repair of the most harmful DNA lesions, DNA double-strand breaks and …
is responsible for repair of the most harmful DNA lesions, DNA double-strand breaks and …
[HTML][HTML] Rad52 inverse strand exchange drives RNA-templated DNA double-strand break repair
OM Mazina, H Keskin, K Hanamshet, F Storici… - Molecular cell, 2017 - cell.com
RNA can serve as a template for DNA double-strand break repair in yeast cells, and Rad52,
a member of the homologous recombination pathway, emerged as an important player in …
a member of the homologous recombination pathway, emerged as an important player in …
Yeast Rad52 is a homodecamer and possesses BRCA2-like bipartite Rad51 binding modes
J Deveryshetty, R Chadda, JR Mattice… - Nature …, 2023 - nature.com
Homologous recombination (HR) is an essential double-stranded DNA break repair
pathway. In HR, Rad52 facilitates the formation of Rad51 nucleoprotein filaments on RPA …
pathway. In HR, Rad52 facilitates the formation of Rad51 nucleoprotein filaments on RPA …
Regulatory mechanisms and clinical perspectives of miRNA in tumor radiosensitivity
L Zhao, AM Bode, Y Cao, Z Dong - Carcinogenesis, 2012 - academic.oup.com
MicroRNA (miRNA) influences carcinogenesis at multiple stages and it can effectively
control tumor radiosensitivity by affecting DNA damage repair, cell cycle checkpoint …
control tumor radiosensitivity by affecting DNA damage repair, cell cycle checkpoint …
Variation of the toxicity caused by key contaminants in industrial wastewater along the treatment train of Fenton-activated sludge-advanced oxidation processes
X Li, H Yang, J Pan, T Liu, X Cao, H Ma, X Wang… - Science of The Total …, 2023 - Elsevier
Industrial wastewater contains a mixture of refractory and hazardous pollutants that have
comprehensive toxic effects. We investigated the treatment of a long-chain industrial …
comprehensive toxic effects. We investigated the treatment of a long-chain industrial …
A checkpoint-related function of the MCM replicative helicase is required to avert accumulation of RNA: DNA hybrids during S-phase and ensuing DSBs during G2/M
S Vijayraghavan, FL Tsai, A Schwacha - PLoS genetics, 2016 - journals.plos.org
The Mcm2-7 complex is the catalytic core of the eukaryotic replicative helicase. Here, we
identify a new role for this complex in maintaining genome integrity. Using both genetic and …
identify a new role for this complex in maintaining genome integrity. Using both genetic and …
Novel RNA and DNA strand exchange activity of the PALB2 DNA binding domain and its critical role for DNA repair in cells
BReast Cancer Associated proteins 1 and 2 (BRCA1,− 2) and Partner and Localizer of
BRCA2 (PALB2) protein are tumour suppressors linked to a spectrum of malignancies …
BRCA2 (PALB2) protein are tumour suppressors linked to a spectrum of malignancies …
MicroRNAs, cancer and ionizing radiation: Where are we?
GN Marta, B Garicochea, AL Carvalho… - Revista da Associacao …, 2015 - SciELO Brasil
The aim of this study is to describe the biogenesis of microRNA, its relations with
carcinogenesis, and the correlation between microRNA and ionizing radiation (IR), focusing …
carcinogenesis, and the correlation between microRNA and ionizing radiation (IR), focusing …
Putative antirecombinase Srs2 DNA helicase promotes noncrossover homologous recombination avoiding loss of heterozygosity
T Miura, T Shibata, K Kusano - Proceedings of the National …, 2013 - National Acad Sciences
DNA damage alone or DNA replication fork arrest at damaged sites may induce DNA double-
strand breaks and initiate homologous recombination. This event can result in a crossover …
strand breaks and initiate homologous recombination. This event can result in a crossover …