Experimental modelling of human disorders enables the definition of the cellular and
molecular mechanisms underlying diseases and the development of therapies for treating …

The cancer stem cell (CSC) hypothesis has captured the attention of many scientists. It is
believed that elimination of CSCs could possibly eradicate the whole cancer. CSC surface …

Age-related macular degeneration (AMD) remains a major cause of blindness, with
dysfunction and loss of retinal pigment epithelium (RPE) central to disease progression. We …

We recently derived mouse expanded potential stem cells (EPSCs) from individual
blastomeres by inhibiting the critical molecular pathways that predispose their differentiation …

Gastrulation controls the emergence of cellular diversity and axis patterning in the early
embryo. In mammals, this transformation is orchestrated by dynamic signalling centres at the …

Human pluripotent stem cells (hPSCs) offer an unprecedented opportunity to model diverse
cell types and tissues. To enable systematic exploration of the programming landscape …

Human pluripotent stem cells (hPS cells) can self-renew indefinitely, making them an
attractive source for regenerative therapies. This expansion potential has been linked with …

Current human pluripotent stem cells lack the transcription factor circuitry that governs the
ground state of mouse embryonic stem cells (ESC). Here, we report that short-term …

Naive pluripotency is manifest in the preimplantation mammalian embryo. Here we
determine transcriptome dynamics of mouse development from the eight-cell stage to …

The worldwide incidence of bone disorders and conditions has trended steeply upward and
is expected to double by 2020, especially in populations where aging is coupled with …