Aptamers are a class of small nucleic acid ligands that are composed of RNA or single-
stranded DNA oligonucleotides and have high specificity and affinity for their targets. Similar …

Today, RNA aptamers are being considered promising theranostic tools against a wide
variety of disorders. RNA aptamers can fold into complex shapes and bind to diverse …

The analysis of circulating tumor cells (CTCs) holds great significance for cancer diagnosis,
prognosis, and personalized therapy. However, the rarity, vulnerability and heterogeneity of …

Synonymous codons occur with different frequencies in different organisms, a phenomenon
termed codon usage bias. Codon optimization, a common term for a variety of approaches …

Although many diagnostic and therapeutic modalities for pancreatic cancer have been
proposed, an urgent need for improved therapeutic strategies remains. Oligonucleotide …

Pancreatic ductal adenocarcinoma (PDAC) is an extremely challenging disease with a high
mortality rate and a short overall survival time. The poor prognosis can be explained by …

Introduction Aptamers provide exciting opportunities for the development of specific and
targeted therapeutic approaches. Areas covered In this review, the authors discuss different …

Circulating tumor cells (CTCs) are cells that shed from a primary tumor and freely circulate in
the blood, retaining the ability to initiate metastasis and form a secondary tumor in distant …

Mammaglobin B (MGB2) and mammaglobin A (MGB1) are proteins expressed in metastatic
breast cancers. The early detection of circulating tumor cells (CTCs) in breast cancer …

Aptamers are single stranded oligonucleotides, comparable to monoclonal antibodies
(mAbs) in selectivity and affinity and have significant strategic properties in design …