BACKGROUND The integrated stress response (ISR) is an evolutionarily conserved
intracellular signaling network that helps the cell, tissue, and organism to adapt to a variable …

Protein synthesis in eukaryotes is a complex process which can be regulated at many points
in the pathway. In recent years it has become clear that both the overall rate of translation …

Exon back-splicing-generated circular RNAs, as a group, can suppress double-stranded
RNA (dsRNA)-activated protein kinase R (PKR) in cells. We have sought to synthesize …

Translation initiation on eukaryotic mRNAs involves 40S ribosome association with mRNA
caps (m7GpppN), mediated by initiation factor eIF4F. 40S eukaryotic ribosomes and …

The RNA-dependent protein kinase (PKR) is an interferon-induced serine/threonine protein
kinase that phosphorylates the α subunit of the eukaryotic initiation factor 2 in response to …

Results In uninfected cells, the tripartite leader initiates translation by both 5'scanning and
ribosome jumping Studies explored whether ribosomes scan all, part, or none of the tripartite …

Adenovirus (Ad) infection results in a marked inhibition of cellular protein synthesis that
initiates during the late phase of the viral infectious cycle. We show that the mechanism used …

Staufen1 is a component of transported ribonucleoprotein complexes. Genetic work in
Drosophila has suggested that Staufen plays a role in the de-repression of translation of …

Eukaryotic viruses have devised numerous strategies to downregulate activity of the
interferon-induced, double-stranded (dsRNA)-activated protein kinase (referred to as p68 on …

To explore the structure and function of a small regulatory RNA, we examined the virus-
associated (VA) RNA species of all 47 known human adenovirus serotypes and of one …