Targeting immunometabolism as an anti-inflammatory strategy
EM Pålsson-McDermott, LAJ O'Neill - Cell research, 2020 - nature.com
The growing field of immunometabolism has taught us how metabolic cellular reactions and
processes not only provide a means to generate ATP and biosynthetic precursors, but are …
processes not only provide a means to generate ATP and biosynthetic precursors, but are …
Protein hydroxylation by hypoxia-inducible factor (HIF) hydroxylases: unique or ubiquitous?
MJ Strowitzki, EP Cummins, CT Taylor - Cells, 2019 - mdpi.com
All metazoans that utilize molecular oxygen (O2) for metabolic purposes have the capacity to
adapt to hypoxia, the condition that arises when O2 demand exceeds supply. This is …
adapt to hypoxia, the condition that arises when O2 demand exceeds supply. This is …
Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression
Cellular senescence is a state of stable proliferative arrest triggered by damaging signals.
Senescent cells persist during aging and promote age-related pathologies via the pro …
Senescent cells persist during aging and promote age-related pathologies via the pro …
HIF hydroxylase pathways in cardiovascular physiology and medicine
T Bishop, PJ Ratcliffe - Circulation research, 2015 - Am Heart Assoc
Hypoxia inducible factors (HIFs) are α/β heterodimeric transcription factors that direct
multiple cellular and systemic responses in response to changes in oxygen availability. The …
multiple cellular and systemic responses in response to changes in oxygen availability. The …
Hypoxia-inducible factors link iron homeostasis and erythropoiesis
Iron is required for efficient oxygen transport, and hypoxia signaling links erythropoiesis with
iron homeostasis. Hypoxia induces a highly conserved signaling pathway in cells under …
iron homeostasis. Hypoxia induces a highly conserved signaling pathway in cells under …
Strategies for creating living, additively manufactured, open-cellular metal and alloy implants by promoting osseointegration, osteoinduction and vascularization: An …
LE Murr - Journal of Materials Science & Technology, 2019 - Elsevier
Additive manufacturing of porous, open-cellular metal or alloy implants, fabricated by laser
or electron beam melting of a powder bed, is briefly reviewed in relation to optimizing …
or electron beam melting of a powder bed, is briefly reviewed in relation to optimizing …
Targeting oxidative stress, a crucial challenge in renal transplantation outcome
R Carcy, M Cougnon, M Poet, M Durandy… - Free Radical Biology …, 2021 - Elsevier
Disorders characterized by ischemia/reperfusion (I/R) are the most common causes of
debilitating diseases and death in stroke, cardiovascular ischemia, acute kidney injury or …
debilitating diseases and death in stroke, cardiovascular ischemia, acute kidney injury or …
Genomic insights into ayurvedic and western approaches to personalized medicine
Ayurveda, an ancient Indian system of medicine documented and practised since 1500 BC,
follows a systems approach that has interesting parallels with contemporary personalized …
follows a systems approach that has interesting parallels with contemporary personalized …
Hypoxia-regulated mechanisms in the pathogenesis of obesity and non-alcoholic fatty liver disease
S Lefere, C Van Steenkiste, X Verhelst… - Cellular and molecular …, 2016 - Springer
The pandemic rise in obesity has resulted in an increased incidence of metabolic
complications. Non-alcoholic fatty liver disease is the hepatic manifestation of the metabolic …
complications. Non-alcoholic fatty liver disease is the hepatic manifestation of the metabolic …
Hypoxia-adaptive pathways: A pharmacological target in fibrotic disease?
MJ Strowitzki, AS Ritter, G Kimmer… - Pharmacological …, 2019 - Elsevier
Wound healing responses are physiological reactions to injuries and share common
characteristics and phases independently of the injured organ or tissue. A major hallmark of …
characteristics and phases independently of the injured organ or tissue. A major hallmark of …