Neutrophils as potential therapeutic targets in hepatocellular carcinoma

D Geh, J Leslie, R Rumney, HL Reeves… - Nature Reviews …, 2022 - nature.com
The success of atezolizumab plus bevacizumab treatment contributed to a shift in systemic
therapies for hepatocellular carcinoma (HCC) towards combinations that include cancer …

Tumor associated neutrophils. Their role in tumorigenesis, metastasis, prognosis and therapy

MT Masucci, M Minopoli, MV Carriero - Frontiers in oncology, 2019 - frontiersin.org
Tumor Associated Neutrophils (TANs) are engaged into the tumor microenvironment by
cytokines and chemokines, can be distinguished according to their activation and cytokine …

Tumour-associated neutrophils in patients with cancer

ME Shaul, ZG Fridlender - Nature reviews Clinical oncology, 2019 - nature.com
The role and importance of neutrophils in cancer has become increasingly apparent over
the past decade. Neutrophils accumulate in the peripheral blood of patients with cancer …

Tumor-infiltrating lymphocytes and their prognostic value in cutaneous melanoma

F Maibach, H Sadozai, SM Seyed Jafari… - Frontiers in …, 2020 - frontiersin.org
Recent breakthroughs in tumor immunotherapy such as immune checkpoint blockade (ICB)
antibodies, have demonstrated the capacity of the immune system to fight cancer in a …

Neutrophils in cancer: neutral no more

SB Coffelt, MD Wellenstein, KE de Visser - Nature Reviews Cancer, 2016 - nature.com
Neutrophils are indispensable antagonists of microbial infection and facilitators of wound
healing. In the cancer setting, a newfound appreciation for neutrophils has come into view …

The role of myeloid cells in cancer therapies

C Engblom, C Pfirschke, MJ Pittet - Nature Reviews Cancer, 2016 - nature.com
Recent clinical trials have demonstrated the ability to durably control cancer in some
patients by manipulating T lymphocytes. These immunotherapies are revolutionizing cancer …

Neutrophils in the tumor microenvironment

DR Powell, A Huttenlocher - Trends in immunology, 2016 - cell.com
Neutrophils are the first responders to sites of acute tissue damage and infection. Recent
studies suggest that in addition to neutrophil apoptosis, resolution of neutrophil inflammation …

Development and validation of an individualized immune prognostic signature in early-stage nonsquamous non–small cell lung cancer

B Li, Y Cui, M Diehn, R Li - JAMA oncology, 2017 - jamanetwork.com
Importance The prevalence of early-stage non–small cell lung cancer (NSCLC) is expected
to increase with recent implementation of annual screening programs. Reliable prognostic …

Neutrophils and PMN-MDSC: Their biological role and interaction with stromal cells

J Zhou, Y Nefedova, A Lei, D Gabrilovich - Seminars in immunology, 2018 - Elsevier
Neutrophils and polymorphonucler myeloid-derived suppressor cells (PMN-MDSC) share
origin and many morphological and phenotypic features. However, they have different …

Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer

EB Eruslanov, PS Bhojnagarwala… - The Journal of …, 2014 - Am Soc Clin Investig
Infiltrating inflammatory cells are highly prevalent within the tumor microenvironment and
mediate many processes associated with tumor progression; however, the contribution of …