The independence of and associations among apoptosis, autophagy, and necrosis
Cell death is an essential biological process for physiological growth and development.
Three classical forms of cell death—apoptosis, autophagy, and necrosis—display distinct …
Three classical forms of cell death—apoptosis, autophagy, and necrosis—display distinct …
Necroptosis
A Linkermann, DR Green - New England Journal of Medicine, 2014 - Mass Medical Soc
Necroptosis | New England Journal of Medicine Skip to main content The New England Journal
of Medicine homepage Advanced Search SEARCH SPECIALTIES Cardiology Clinical Medicine …
of Medicine homepage Advanced Search SEARCH SPECIALTIES Cardiology Clinical Medicine …
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
L Galluzzi, BS Pedro, I Vitale, SA Aaronson… - Cell Death & …, 2015 - nature.com
Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable
manner, as a result of their immediate structural breakdown. Such an unavoidable variant of …
manner, as a result of their immediate structural breakdown. Such an unavoidable variant of …
Apoptosis, necrosis and necroptosis: cell death regulation in the intestinal epithelium
Intestinal epithelial cells (IEC) are organised as a single cell layer which covers the intestine.
Their primary task is to absorb nutrients present in the intestinal lumen. However, IEC also …
Their primary task is to absorb nutrients present in the intestinal lumen. However, IEC also …
Origin and consequences of necroinflammation
M Sarhan, WG Land, W Tonnus… - Physiological …, 2018 - journals.physiology.org
When cells undergo necrotic cell death in either physiological or pathophysiological settings
in vivo, they release highly immunogenic intracellular molecules and organelles into the …
in vivo, they release highly immunogenic intracellular molecules and organelles into the …
Molecular mechanisms of regulated necrosis
It is now clear that apoptosis does not constitute the sole genetically encoded form of cell
death. Rather, cells can spontaneously undertake or exogenously be driven into a cell death …
death. Rather, cells can spontaneously undertake or exogenously be driven into a cell death …
[HTML][HTML] Survival function of the FADD-CASPASE-8-cFLIPL complex
CP Dillon, A Oberst, R Weinlich, LJ Janke, TB Kang… - Cell reports, 2012 - cell.com
Caspase-8, the initiator caspase of the death receptor pathway of apoptosis, its adapter
molecule, FADD, required for caspase-8 activation, and cFLIP L, a caspase-8-like protein …
molecule, FADD, required for caspase-8 activation, and cFLIP L, a caspase-8-like protein …
Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A‐RIPK1‐dependent necroptosis
Mechanisms that alter protein phosphatase 2A (PP2A)‐dependent lung tumour suppression
via the I2PP2A/SET oncoprotein are unknown. We show here that the tumour suppressor …
via the I2PP2A/SET oncoprotein are unknown. We show here that the tumour suppressor …
Deletion of c-FLIP from CD11bhi Macrophages Prevents Development of Bleomycin-induced Lung Fibrosis
AL McCubbrey, L Barthel, MP Mohning… - American journal of …, 2018 - atsjournals.org
Idiopathic pulmonary fibrosis is a progressive lung disease with complex pathophysiology
and fatal prognosis. Macrophages (MΦ) contribute to the development of lung fibrosis; …
and fatal prognosis. Macrophages (MΦ) contribute to the development of lung fibrosis; …
Killing a cancer: what are the alternatives?
P Kreuzaler, CJ Watson - Nature Reviews Cancer, 2012 - nature.com
Evading programmed cell death is one of the hallmarks of cancer. Conversely, inducing cell
death by pharmacological means is the basis of almost every non-invasive cancer therapy …
death by pharmacological means is the basis of almost every non-invasive cancer therapy …