Thirty years of resistance: Zig-zag through the plant immune system

BPM Ngou, P Ding, JDG Jones - The Plant Cell, 2022 - academic.oup.com
Understanding the plant immune system is crucial for using genetics to protect crops from
diseases. Plants resist pathogens via a two-tiered innate immune detection-and-response …

[HTML][HTML] Plant immunity: danger perception and signaling

JM Zhou, Y Zhang - Cell, 2020 - cell.com
Plants employ numerous cell-surface and intracellular immune receptors to perceive a
variety of immunogenic signals associated with pathogen infection and subsequently …

Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme

S Ma, D Lapin, LI Liu, Y Sun, W Song, X Zhang… - Science, 2020 - science.org
INTRODUCTION Discrimination of self from nonself is pivotal for cellular organisms, as it
allows the perception of pathogenic invaders that might otherwise multiply unchecked and …

[HTML][HTML] TIR domains of plant immune receptors are 2′, 3′-cAMP/cGMP synthetases mediating cell death

D Yu, W Song, EYJ Tan, L Liu, Y Cao, J Jirschitzka, E Li… - Cell, 2022 - cell.com
Summary 2′, 3′-cAMP is a positional isomer of the well-established second messenger
3′, 5′-cAMP, but little is known about the biology of this noncanonical cyclic nucleotide …

The plant hypersensitive response: concepts, control and consequences

P Balint‐Kurti - Molecular plant pathology, 2019 - Wiley Online Library
The hypersensitive defence response is found in all higher plants and is characterized by a
rapid cell death at the point of pathogen ingress. It is usually associated with pathogen …

NAD+ cleavage activity by animal and plant TIR domains in cell death pathways

S Horsefield, H Burdett, X Zhang, MK Manik, Y Shi… - Science, 2019 - science.org
SARM1 (sterile alpha and TIR motif containing 1) is responsible for depletion of
nicotinamide adenine dinucleotide in its oxidized form (NAD+) during Wallerian …

Structure of the activated ROQ1 resistosome directly recognizing the pathogen effector XopQ

R Martin, T Qi, H Zhang, F Liu, M King, C Toth… - Science, 2020 - science.org
INTRODUCTION Plants and animals respond to pathogen invasion through intracellular
nucleotide-binding leucine-rich repeat receptors (NLRs) that directly interact with pathogen …

TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death

L Wan, K Essuman, RG Anderson, Y Sasaki… - Science, 2019 - science.org
Plant nucleotide-binding leucine-rich repeat (NLR) immune receptors activate cell death and
confer disease resistance by unknown mechanisms. We demonstrate that plant …

Intracellular innate immune surveillance devices in plants and animals

JDG Jones, RE Vance, JL Dangl - Science, 2016 - science.org
BACKGROUND Pathogens cause agricultural devastation and huge economic losses. Up to
30% of our crops are lost before or after harvest to pathogens and pests, wasting water and …

The NAD+-mediated self-inhibition mechanism of pro-neurodegenerative SARM1

Y Jiang, T Liu, CH Lee, Q Chang, J Yang, Z Zhang - Nature, 2020 - nature.com
Pathological degeneration of axons disrupts neural circuits and represents one of the
hallmarks of neurodegeneration,,–. Sterile alpha and Toll/interleukin-1 receptor motif …