The adult central nervous system (CNS) of the zebrafish, owing to its enrichment in
constitutive neurogenic niches, is becoming an increasingly used model to address …

Tissue or organ regeneration is a complex process with successful outcomes depending on
the type of tissue and organism. Upon damage, mammals can only efficiently restore a few …

Unlike adult mammals, zebrafish regenerate spinal cord tissue and recover locomotor ability
after a paralyzing injury. Here, we find that ependymal cells in zebrafish spinal cords …

The mechanical properties of biological tissues are increasingly recognized as important
factors in developmental and pathological processes. Most existing mechanical …

The inhibitory extracellular matrix in a spinal lesion site is a major impediment to axonal
regeneration in mammals. In contrast, the extracellular matrix in zebrafish allows substantial …

Zebrafish exhibit robust regeneration following spinal cord injury, promoted by macrophages
that control post-injury inflammation. However, the mechanistic basis of how macrophages …

In adult zebrafish, relatively quiescent progenitor cells show lesion-induced generation of
motor neurons. Developmental motor neuron generation from the spinal motor neuron …

Spinal cord injury results in permanent sensorimotor loss in mammals, in part due to a lack
of injury-induced neurogenesis. The regeneration of neurons depends upon resident neural …

Regeneration in the animal kingdom is one of the most fascinating problems that have
allowed scientists to address many issues of fundamental importance in basic biology …

Spinal cord injury results in the loss of neurons and axonal connections. In mammals,
including humans, this loss is permanent, but is repaired in other vertebrates, such as …