Heart failure (HF) continues to be a highly prevalent syndrome, affecting millions of patients
and costing billions of dollars in treatment per year in the United States alone. Studies in …

Platelets are active key players in haemostasis. Qualitative platelet dysfunctions result in
thrombocytopathies variously characterized by defects of their adhesive and procoagulant …

Physical activity is beneficial for health, for example, by lowering the risk of cardiovascular
events. However, vigorous exercise is associated with the occurrence of thromboembolic …

Dysregulation of vascular endothelial growth factor (VEGF) and its receptor (VEGFR)
contributes to atherosclerosis and cardiovascular disease (CVD), making it a potential target …

Recent connections between platelet activity and cardiovascular disease have raised
questions of whether platelet function varies in exercising individuals. Resistance training …

Adrenaline has recently been found to trigger phosphatidylserine (PS) exposure on blood
platelets, resulting in amplification of the coagulation process, but the mechanism is only …

Platelet dysfunction can cause clinically relevant bleeding. Treatment with DDAVP is
advocated for this condition. DDAVP increases von Willebrand factor (VWF) on endothelial …

Rise in mean platelet volume (MPV) has been demonstrated to be associated with
increased platelet reactivity. In diabetes patients, augmented MPV was proposed to …

We tested the hypothesis that in vitro peroxynitrite (ONOO−, a product of activated
inflammatory cells) may affect fibrinolysis in human blood through the reduction of platelet …

Importance of the field: The sodium/hydrogen exchanger-1 (NHE-1/SLC9A1) is a ubiquitous
plasma membrane protein whose main role is maintenance of intracellular pH and volume …