Imperfect wound healing sets the stage for chronic diseases

P Martin, C Pardo-Pastor, RG Jenkins, J Rosenblatt - Science, 2024 - science.org
Although the age of the genome gave us much insight about how our organs fail with
disease, it also suggested that diseases do not arise from mutations alone; rather, they …

ECM and epithelial stem cells: the scaffold of destiny

S Estrach, CM Vivier, CC Féral - Frontiers in Cell and Developmental …, 2024 - frontiersin.org
Adult stem cells play a critical role in maintaining tissue homeostasis and promoting
longevity. The intricate organization and presence of common markers among adult …

An engineered AAV targeting integrin alpha V beta 6 presents improved myotropism across species

A Vu Hong, L Suel, E Petat, A Dubois… - Nature …, 2024 - nature.com
Current adeno-associated virus (AAV) gene therapy using nature-derived AAVs is limited by
non-optimal tissue targeting. In the treatment of muscular diseases (MD), high doses are …

Aging-associated molecular changes in human alveolar type I cells

X Liu, X Zhang, J Liang, PW Noble… - Journal of respiratory …, 2024 - pmc.ncbi.nlm.nih.gov
Human alveolar type I (AT1) cells are specialized epithelial cells that line the alveoli in the
lungs where gas exchange occurs. The primary function of AT1 cells is not only to facilitate …

C-phycocyanin reinforces autophagy to block pulmonary fibrogenesis by inhibiting lncIAPF biogenesis

W Hu, Y Wang, H Yang, L Zhang, B Liu, Y Ji… - Archives of Pharmacal …, 2024 - Springer
Pulmonary fibrosis is a chronic and irreversible progressive lung disease caused by various
factors, such as age and environmental pollution. With countries stepping into an aging …

Validation of a Non-Invasive Lung Monitor Using Murine Models of Lung Damage and Therapeutic Intervention

K Kenny - 2024 - search.proquest.com
The lung is a critical interface between an organism and its environment, responsible for
supplying oxygen to the organism's cells. Lung function is negatively impacted by both aging …

Lung regeneration and lung bioengineering

E Cohen - Current Opinion in Anesthesiology - journals.lww.com
The lung's ability to regenerate extensively after injury suggests that this capability could be
promoted in diseases in which loss of lung tissue occurs. Lung bioengineering offers the …

Doença Pulmonar Obstrutiva Crónica: novas abordagens terapêuticas

AFRB Azevedo - 2023 - repositorio.ul.pt
Esta monografia procura explorar de forma abrangente a Doença Pulmonar Obstrutiva
Crónica, focando-se nas suas características fundamentais e no impacto das estratégias …

Doença Pulmonar Obstrutiva Crónica: Novas Abordagens Terapêuticas

AFRB de Azevedo - 2023 - search.proquest.com
Esta monografia procura explorar de forma abrangente a Doença Pulmonar Obstrutiva
Crónica, focando-se nas suas características fundamentais e no impacto das estratégias …