[HTML][HTML] Kidney fibrosis: from mechanisms to therapeutic medicines
R Huang, P Fu, L Ma - Signal Transduction and Targeted Therapy, 2023 - nature.com
Chronic kidney disease (CKD) is estimated to affect 10–14% of global population. Kidney
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …
Targeting the progression of chronic kidney disease
Chronic kidney disease (CKD) is a devastating condition that is reaching epidemic levels
owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well …
owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well …
Mitochondrial quality control in kidney injury and repair
C Tang, J Cai, XM Yin, JM Weinberg… - Nature Reviews …, 2021 - nature.com
Mitochondria are essential for the activity, function and viability of eukaryotic cells and
mitochondrial dysfunction is involved in the pathogenesis of acute kidney injury (AKI) and …
mitochondrial dysfunction is involved in the pathogenesis of acute kidney injury (AKI) and …
Autophagy in kidney homeostasis and disease
C Tang, MJ Livingston, Z Liu, Z Dong - Nature Reviews Nephrology, 2020 - nature.com
Autophagy is a conserved lysosomal pathway for the degradation of cytoplasmic
components. Basal autophagy in kidney cells is essential for the maintenance of kidney …
components. Basal autophagy in kidney cells is essential for the maintenance of kidney …
Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury
Y Kirita, H Wu, K Uchimura… - Proceedings of the …, 2020 - National Acad Sciences
After acute kidney injury (AKI), patients either recover or alternatively develop fibrosis and
chronic kidney disease. Interactions between injured epithelia, stroma, and inflammatory …
chronic kidney disease. Interactions between injured epithelia, stroma, and inflammatory …
[HTML][HTML] Timing of initiation of renal-replacement therapy in acute kidney injury.
SM Bagshaw, R Wald, NKJ Adhikari, R Bellomo… - The New England …, 2020 - sonar.ch
We conducted a multinational, randomized, controlled trial involving critically ill patients with
severe acute kidney injury. Patients were randomly assigned to receive an accelerated …
severe acute kidney injury. Patients were randomly assigned to receive an accelerated …
Single-nuclear transcriptomics reveals diversity of proximal tubule cell states in a dynamic response to acute kidney injury
LMS Gerhardt, J Liu, K Koppitch… - Proceedings of the …, 2021 - National Acad Sciences
Acute kidney injury (AKI), commonly caused by ischemia, sepsis, or nephrotoxic insult, is
associated with increased mortality and a heightened risk of chronic kidney disease (CKD) …
associated with increased mortality and a heightened risk of chronic kidney disease (CKD) …
[HTML][HTML] Chronic critical illness and post-intensive care syndrome: from pathophysiology to clinical challenges
G Voiriot, M Oualha, A Pierre… - Annals of intensive …, 2022 - Springer
Background Post‐intensive care syndrome (PICS) encompasses physical, cognition, and
mental impairments persisting after intensive care unit (ICU) discharge. Ultimately it …
mental impairments persisting after intensive care unit (ICU) discharge. Ultimately it …
[HTML][HTML] Exosomal miR-125b-5p deriving from mesenchymal stem cells promotes tubular repair by suppression of p53 in ischemic acute kidney injury
JY Cao, B Wang, TT Tang, Y Wen, ZL Li, ST Feng… - Theranostics, 2021 - ncbi.nlm.nih.gov
Mesenchymal stem cells-derived exosomes (MSC-exos) have attracted great interest as a
cell-free therapy for acute kidney injury (AKI). However, the in vivo biodistribution of MSC …
cell-free therapy for acute kidney injury (AKI). However, the in vivo biodistribution of MSC …
[HTML][HTML] KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease
Tubulointerstitial abnormalities are predictive of the progression of diabetic kidney disease
(DKD), and their targeting may be an effective means for prevention. Proximal tubular (PT) …
(DKD), and their targeting may be an effective means for prevention. Proximal tubular (PT) …