Background Therapeutic drug monitoring and Model-informed precision dosing allow dose
individualization to increase drug effectivity and reduce toxicity. Objectives To evaluate the …

Critically ill patients have increased variability in beta-lactam antibiotic (beta-lactam)
exposure due to alterations in their volume of distribution and elimination. Therapeutic drug …

The increasing incidence of antimicrobial resistance (AMR) worldwide represents a serious
threat in the management of sepsis. Due to resistance to the most common antimicrobials …

Beta-lactam antibiotics remain one of the most preferred groups of antibiotics in critical care
due to their excellent safety profiles and their activity against a wide spectrum of pathogens …

Mortality in critically ill patients decreased over the last decades and standards of care are
constantly evolving to achieve further reductions. 1 Despite these progressions, critical care …

Cefepime exhibits highly variable pharmacokinetics in critically ill patients. The purpose of
this study was to develop and qualify a population pharmacokinetic model for use in the …

Background The efficacy of therapeutic drug monitoring (TDM)-based antimicrobial dosing
optimization strategies on pharmacokinetics/pharmacodynamics and specific drug …

An estimated 70% of critically ill patients receive antibiotics, most frequently beta-lactams.
The pharmacokinetic properties of these substances in this patient population are poorly …

Background: Sepsis is a complex, life-threatening clinical syndrome that can cause other
related diseases, such as acute kidney injury (AKI). Circular RNA (circRNA) is a type of non …

Artificial intelligence (AI) is an emerging technology with numerous healthcare applications.
AI could prove particularly useful in the cardiac intensive care unit (CICU) where its capacity …