This review summarizes ongoing research aimed at finding novel drugs as alternatives to
traditional antibiotics. Anti-virulence approaches, phage therapy and therapeutic antibodies …

Surface proteins play a critical role in the interaction between cells and their environment, as
they take part in processes like signaling, adhesion, transport, etc. In pathogenic …

Lactobacillus rhamnosus GG (GG) is a widely used and intensively studied probiotic
bacterium. Although the health benefits of strain GG are well documented, the systematic …

We propose an experimental strategy for highly accurate selection of candidates for
bacterial vaccines without using in vitro and/or in vivo protection assays. Starting from the …

Proteins expressed on the bacterial cell surface play important roles in infection and
virulence and can be targets for vaccine development or used as biomarkers. Surprisingly …

Vaccination is historically one of the most important medical interventions for the prevention
of infectious disease. Previously, vaccines were typically made of rather crude mixtures of …

Streptococcus agalactiae (group B streptococcus, GBS) is a leading causal organism of
neonatal invasive diseases and severe infections in the elderly. Despite significant …

Antibiotic resistance has emerged as one of the greatest global health challenges to be
addressed in the 21st Century. The risk of widespread antibiotic resistance threatens to …

An unprecedented increase in new vaccine development has occurred over the past three
decades. This activity has resulted in vaccines that protect against an increased range of …

Reverse vaccinology (RV), the first application of genomic technologies in vaccine research,
represented a major revolution in the process of discovering novel vaccines. By determining …