Single-cell metabolomics: analytical and biological perspectives
R Zenobi - Science, 2013 - science.org
Background In recent years, there has been a surge in the development and application of
single-cell genomics, transcriptomics, proteomics, and metabolomics. The metabolome is …
single-cell genomics, transcriptomics, proteomics, and metabolomics. The metabolome is …
New developments in biochemical mass spectrometry: electrospray ionization
Over the past two decades mass spectrometry has advanced to the point where it has
become one of the most broadly applicable tools in analytical chemistry. The rapid pace of …
become one of the most broadly applicable tools in analytical chemistry. The rapid pace of …
Reversed-phase liquid chromatography of peptides for bottom-up proteomics: a tutorial
J Lenco, S Jadeja, DK Naplekov… - Journal of Proteome …, 2022 - ACS Publications
The performance of the current bottom-up liquid chromatography hyphenated with mass
spectrometry (LC-MS) analyses has undoubtedly been fueled by spectacular progress in …
spectrometry (LC-MS) analyses has undoubtedly been fueled by spectacular progress in …
Electrochemical monitoring of single cell secretion: vesicular exocytosis and oxidative stress
C Amatore, S Arbault, M Guille, F Lemaitre - Chemical reviews, 2008 - ACS Publications
Communication between cellular organisms occurs, among other mechanisms, through the
release of specific biochemical or chemical messengers by an emitting cell, generally …
release of specific biochemical or chemical messengers by an emitting cell, generally …
Microfluidic platforms for single-cell analysis
Microfluidics, the study and control of the fluidic behavior in microstructures, has emerged as
an important enabling tool for single-cell chemical analysis. The complex procedures for …
an important enabling tool for single-cell chemical analysis. The complex procedures for …
Overview of single-cell analyses: microdevices and applications
S Lindström, H Andersson-Svahn - Lab on a Chip, 2010 - pubs.rsc.org
Numerous microdevices developed for single-cell analyses have been presented in the last
decades. Practical usefulness in biological and clinical settings has become an important …
decades. Practical usefulness in biological and clinical settings has become an important …
Discovery of endogenous catecholamines in lymphocytes and evidence for catecholamine regulation of lymphocyte function via an autocrine loop.
J Bergquist, A Tarkowski, R Ekman… - Proceedings of the …, 1994 - National Acad Sciences
Evidence has been obtained that catecholamines and their metabolites are present in single
lymphocytes and extracts of T-and B-cell clones by use of capillary electrophoresis with …
lymphocytes and extracts of T-and B-cell clones by use of capillary electrophoresis with …
Analysis of single mammalian cells on-chip
CE Sims, NL Allbritton - Lab on a Chip, 2007 - pubs.rsc.org
A goal of modern biology is to understand the molecular mechanisms underlying cellular
function. The ability to manipulate and analyze single cells is crucial for this task. The advent …
function. The ability to manipulate and analyze single cells is crucial for this task. The advent …
In situ metabolic profiling of single cells by laser ablation electrospray ionization mass spectrometry
B Shrestha, A Vertes - Analytical chemistry, 2009 - ACS Publications
Depending on age, phase in the cell cycle, nutrition, and environmental factors, individual
cells exhibit large metabolic diversity. To explore metabolic variations in cell populations …
cells exhibit large metabolic diversity. To explore metabolic variations in cell populations …
Integration of single cell injection, cell lysis, separation and detection of intracellular constituents on a microfluidic chip
J Gao, XF Yin, ZL Fang - Lab on a Chip, 2004 - pubs.rsc.org
A microfluidic system was developed for the analysis of single biological cells, with
functional integration of cell sampling, single cell loading, docking, lysing, and capillary …
functional integration of cell sampling, single cell loading, docking, lysing, and capillary …