Impact of aging on immunity in the context of COVID-19, HIV, and tuberculosis

A Grifoni, T Alonzi, G Alter, DMC Noonan… - Frontiers in …, 2023 - frontiersin.org
Knowledge of aging biology needs to be expanded due to the continuously growing number
of elderly people worldwide. Aging induces changes that affect all systems of the body. The …

Multiplex interrogation of the NK cell signalome reveals global downregulation of CD16 signaling during lentivirus infection through an IL-18/ADAM17-dependent …

S Sugawara, B Hueber, G Woolley, K Terry… - Plos …, 2023 - journals.plos.org
Despite their importance, natural killer (NK) cell responses are frequently dysfunctional
during human immunodeficiency virus-1 (HIV-1) and simian immunodeficiency virus (SIV) …

Machine learning models based on fluid immunoproteins that predict non-AIDS adverse events in people with HIV

TA Premeaux, S Bowler, CM Friday, CB Moser… - Iscience, 2024 - cell.com
Despite the success of antiretroviral therapy (ART), individuals with HIV remain at risk for
experiencing non-AIDS adverse events (NAEs), including cardiovascular complications and …

Knockdowns of CD3zeta Chain in Primary NK Cells Illustrate Modulation of Antibody-Dependent Cellular Cytotoxicity Against Human Immunodeficiency Virus-1

S Sugawara, E Lee, MA Craemer, A Pruitt… - AIDS Research and …, 2024 - liebertpub.com
Multifaceted natural killer (NK) cell activities are indispensable for controlling human
immunodeficiency virus (HIV)-1 transmission and pathogenesis. Among the diverse …

Multiplex analysis of cytokines and chemokines in persons aging with or without HIV

KW Kroll, G Woolley, K Terry, TA Premeaux… - AIDS Research and …, 2023 - liebertpub.com
People with HIV (PWH) on combination antiretroviral therapy (cART) are living longer lives
due to modern cART advances and increased routine medical care. The full landscape of …

[HTML][HTML] Protocol for identification and computational analysis of human natural killer cells using flow cytometry and R

K Kroll, RK Reeves - STAR protocols, 2023 - Elsevier
Identifying differential protein expression is routinely used to delineate natural killer (NK)
cells from various sample cohorts. This protocol describes key steps for NK cell analysis …