Deciphering the principles and mechanisms by which gene activity orchestrates complex
cellular arrangements in multicellular organisms has far-reaching implications for research …

The combination of spatial transcriptomics (ST) and single cell RNA sequencing (scRNA-
seq) acts as a pivotal component to bridge the pathological phenomes of human tissues with …

In the past decades, transcriptomic studies have revolutionized cancer treatment and
diagnosis. However, tumor sequencing strategies typically result in loss of spatial …

During adaptive immunity, B cells differentiate either into memory B cells or plasma cells and
produce antibodies against foreign antigens to fight infection. Additionally, they behave as …

Background Recent advancements in in situ gene expression technologies constitute a new
and rapidly evolving field of transcriptomics. With the recent launch of the 10x Genomics …

Glioblastoma (GBM) is a particularly devastating tumor with a median survival of about 16
months. Recent research has revealed novel insights into the outstanding heterogeneity of …

In the skin, tissue injury results in fibrosis in the form of scars composed of dense
extracellular matrix deposited by fibroblasts. The therapeutic goal of regenerative wound …

The inflamed rheumatic joint is a highly heterogeneous and complex tissue with dynamic
recruitment and expansion of multiple cell types that interact in multifaceted ways within a …

Deciphering the cellular composition in genome-wide spatially resolved transcriptomic data
is a critical task to clarify the spatial context of cells in a tissue. In this study, we developed a …

Background How T follicular (Tfh) cells contribute to many different B-cell class-switching
events during T-cell–dependent immune responses has been unclear. Diseases with …