In many eukaryotes, including mammals, plants, yeast, and insects, introns can increase
gene expression without functioning as a binding site for transcription factors. This …

The intron has been a big biological mystery since it was first discovered in several aspects.
First, all of the completely sequenced eukaryotes harbor introns in the genomic structure …

Mammalian genomes are pervasively transcribed, to produce thousands of long non-coding
RNAs (lncRNAs),. A few of these lncRNAs have been shown to recruit regulatory complexes …

Noncoding RNAs (ncRNAs) have numerous roles in development and disease, and one of
the prominent roles is to regulate gene expression. A vast number of circular RNAs …

The expansion of introns within mammalian genomes poses a challenge for the production
of full-length messenger RNAs (mRNAs), with increasing evidence that these long AT-rich …

Microbial oil production by heterotrophic organisms is a promising path for the cost-effective
production of biofuels from renewable resources provided high conversion yields can be …

Alternative precursor messenger RNA (pre-mRNA) splicing plays a pivotal role in the flow of
genetic information from DNA to proteins by expanding the coding capacity of genomes …

The smallest viable unit of life is the cell. From bacteria to mammals, all cells use the same
nucleic acid-based universal code for the maintenance and inheritance of genetic …

Precursor mRNA splicing is one of the most highly regulated processes in metazoan
species. In addition to generating vast repertoires of RNAs and proteins, splicing has a …

The pathway from gene activation in the nucleus to mRNA translation and decay at specific
locations in the cytoplasm is both streamlined and highly interconnected. This review …