Parkinson's disease is the second most common neurodegenerative disease and its
prevalence has been projected to double over the next 30 years. An accurate diagnosis of …

Synucleinopathies are clinically and pathologically heterogeneous disorders characterized
by pathologic aggregates of α-synuclein in neurons and glia, in the form of Lewy bodies …

Analysis of human pathology led Braak to postulate that α-synuclein (α-syn) pathology could
spread from the gut to brain via the vagus nerve. Here, we test this postulate by assessing α …

Growing evidence suggests an increasing significance for the extent of gastrointestinal tract
(GIT) dysfunction in Parkinson's disease (PD). Most patients suffer from GIT symptoms …

Many of the motor symptoms of Parkinson disease (PD) can be preceded, sometimes for
several years, by non-motor symptoms that include hyposmia, sleep disorders, depression …

So-called idiopathic rapid eye movement (REM) sleep behaviour disorder (RBD), formerly
seen as a rare parasomnia, is now recognized as the prodromal stage of an α …

The conversion of endogenous alpha-synuclein (asyn) to pathological asyn-enriched
aggregates is a hallmark of Parkinson's disease (PD). These inclusions can be detected in …

Parkinson disease (PD) follows a defined clinical pattern, and a range of nonmotor
symptoms precede the motor phase. The predominant early nonmotor manifestations are …

A relatively small number of especially susceptible nerve cell types within multiple
neurotransmitter systems of the human central, peripheral, and enteric nervous systems …

Definitive diagnosis of Parkinson's disease (PD) and dementia with Lewy bodies (DLB)
relies on postmortem finding of disease-associated alpha-synuclein (αSyn D) as misfolded …