Pathomechanisms of paclitaxel-induced peripheral neuropathy
I Klein, HC Lehmann - Toxics, 2021 - mdpi.com
Peripheral neuropathy is one of the most common side effects of chemotherapy, affecting up
to 60% of all cancer patients receiving chemotherapy. Moreover, paclitaxel induces …
to 60% of all cancer patients receiving chemotherapy. Moreover, paclitaxel induces …
Pathogenesis of paclitaxel-induced peripheral neuropathy: A current review of in vitro and in vivo findings using rodent and human model systems
NP Staff, JC Fehrenbacher, M Caillaud, MI Damaj… - Experimental …, 2020 - Elsevier
Abstract Paclitaxel (Brand name Taxol) is widely used in the treatment of common cancers
like breast, ovarian and lung cancer. Although highly effective in blocking tumor progression …
like breast, ovarian and lung cancer. Although highly effective in blocking tumor progression …
The innate immune system in diabetic retinopathy
WW Pan, F Lin, PE Fort - Progress in retinal and eye research, 2021 - Elsevier
The prevalence of diabetes has been rising steadily in the past half-century, along with the
burden of its associated complications, including diabetic retinopathy (DR). DR is currently …
burden of its associated complications, including diabetic retinopathy (DR). DR is currently …
Chemotherapy-induced peripheral neuropathy: part 1—current state of knowledge and perspectives for pharmacotherapy
K Sałat - Pharmacological reports, 2020 - Springer
Background Despite the increasing knowledge of the etiology of neuropathic pain, this type
of chronic pain is resistant to available analgesics in approximately 50% of patients and …
of chronic pain is resistant to available analgesics in approximately 50% of patients and …
The complement cascade in the regulation of neuroinflammation, nociceptive sensitization, and pain
The complement cascade is a key component of the innate immune system that is rapidly
recruited through a cascade of enzymatic reactions to enable the recognition and clearance …
recruited through a cascade of enzymatic reactions to enable the recognition and clearance …
Principles of genetic engineering
TM Lanigan, HC Kopera, TL Saunders - Genes, 2020 - mdpi.com
Genetic engineering is the use of molecular biology technology to modify DNA sequence (s)
in genomes, using a variety of approaches. For example, homologous recombination can be …
in genomes, using a variety of approaches. For example, homologous recombination can be …
Rat models of human diseases and related phenotypes: a systematic inventory of the causative genes
C Szpirer - Journal of biomedical science, 2020 - Springer
The laboratory rat has been used for a long time as the model of choice in several
biomedical disciplines. Numerous inbred strains have been isolated, displaying a wide …
biomedical disciplines. Numerous inbred strains have been isolated, displaying a wide …
Neurons and microglia; a sickly-sweet duo in diabetic pain neuropathy
T Rajchgot, SC Thomas, JC Wang, M Ahmadi… - Frontiers in …, 2019 - frontiersin.org
Diabetes is a common condition characterized by persistent hyperglycemia. High blood
sugar primarily affects cells that have a limited capacity to regulate their glucose intake …
sugar primarily affects cells that have a limited capacity to regulate their glucose intake …
Evodiamine ameliorates paclitaxel-induced neuropathic pain by inhibiting inflammation and maintaining mitochondrial anti-oxidant functions
P Wu, Y Chen - Human Cell, 2019 - Springer
Chemotherapy-induced neuropathic pain (CINP) is a common and debilitating side effect of
cancer treatment. Evodiamine, a major effective compound isolated from Evodia rutaecarpa …
cancer treatment. Evodiamine, a major effective compound isolated from Evodia rutaecarpa …
Paclitaxel-induced peripheral neuropathy is caused by epidermal ROS and mitochondrial damage through conserved MMP-13 activation
AM Cirrincione, AD Pellegrini, JR Dominy… - Scientific reports, 2020 - nature.com
Paclitaxel induces peripheral neuropathy as a side effect of cancer treatment. The
underlying causes are unclear, but epidermal, unmyelinated axons have been shown to be …
underlying causes are unclear, but epidermal, unmyelinated axons have been shown to be …