Peripheral neuropathy is one of the most common side effects of chemotherapy, affecting up
to 60% of all cancer patients receiving chemotherapy. Moreover, paclitaxel induces …

Abstract Paclitaxel (Brand name Taxol) is widely used in the treatment of common cancers
like breast, ovarian and lung cancer. Although highly effective in blocking tumor progression …

The prevalence of diabetes has been rising steadily in the past half-century, along with the
burden of its associated complications, including diabetic retinopathy (DR). DR is currently …

Background Despite the increasing knowledge of the etiology of neuropathic pain, this type
of chronic pain is resistant to available analgesics in approximately 50% of patients and …

The complement cascade is a key component of the innate immune system that is rapidly
recruited through a cascade of enzymatic reactions to enable the recognition and clearance …

Genetic engineering is the use of molecular biology technology to modify DNA sequence (s)
in genomes, using a variety of approaches. For example, homologous recombination can be …

The laboratory rat has been used for a long time as the model of choice in several
biomedical disciplines. Numerous inbred strains have been isolated, displaying a wide …

Diabetes is a common condition characterized by persistent hyperglycemia. High blood
sugar primarily affects cells that have a limited capacity to regulate their glucose intake …

Chemotherapy-induced neuropathic pain (CINP) is a common and debilitating side effect of
cancer treatment. Evodiamine, a major effective compound isolated from Evodia rutaecarpa …

Paclitaxel induces peripheral neuropathy as a side effect of cancer treatment. The
underlying causes are unclear, but epidermal, unmyelinated axons have been shown to be …