Genetic alterations affecting transforming growth factor–β (TGF-β) signaling are
exceptionally common in diseases and cancers of the gastrointestinal system. As a regulator …

Our understanding of celiac disease and how it develops has evolved significantly over the
last half century. Although traditionally viewed as a pediatric illness characterized by …

Purpose The only effective and safe treatment of celiac disease (CD) continues being strict
exclusion of gluten for life, the so-called gluten-free diet (GFD). Although this treatment is …

The intraepithelial lymphocytes (IELs) that reside within the epithelium of the intestine form
one of the main branches of the immune system. As IELs are located at this critical interface …

Growing knowledge about the cytokine network response has led to a better comprehension
of mechanisms of pathologies and to the development of new treatments with biological …

Celiac disease has become one of the best-understood HLA-linked disorders. Although it
shares many immunologic features with inflammatory bowel disease, celiac disease is …

Coeliac disease is a chronic inflammatory disorder of the small bowel induced in genetically
susceptible people by the irritant gluten and possibly other environmental cofactors. The …

Several studies point towards alteration in gut microbiota composition and function in
coeliac disease, some of which can precede the onset of disease and/or persist when …

Background Natural killer cell cytotoxicity is decreased in patients with acute myeloid
leukemia in comparison to that in normal controls. Tumor-derived microvesicles present in …

Summary Interleukin‐15 (IL‐15) exerts many biological functions essential for the
maintenance and function of multiple cell types. Although its expression is tightly regulated …