Cancer cells adapt to varying stress conditions to survive through plasticity. Stem cells
exhibit a high degree of plasticity, allowing them to generate more stem cells or differentiate …

Simple Summary The aim of this review is to summarize lamin A/C's currently known
functions in both normal and diseased cells. Lamin A/C is a nuclear protein with many …

Yes-associated protein (YAP) is a key mechanotransduction protein in diverse physiological
and pathological processes; however, a ubiquitous YAP activity regulatory mechanism in …

Aberrations in nuclear size and shape are commonly used to identify cancerous tissue.
However, it remains unclear whether the disturbed nuclear structure directly contributes to …

Metastatic progression is the deadliest feature of cancer. Cancer cell growth, invasion,
intravasation, circulation, arrest/adhesion and extravasation require specific mechanical …

Irregularities in nuclear shape and/or alterations to nuclear size are a hallmark of
malignancy in a broad range of cancer types. Though these abnormalities are commonly …

Many tumors prefer to metastasize to bone, but the underlying mechanisms remain elusive.
The human skeletal system has unique physical properties, that are distinct from other …

Despite significant advances in our understanding of tumourigenesis and cancer
therapeutics, cancer continues to account for 30% of worldwide deaths. Therefore, there …

During metastasis, tumour cells navigating the vascular circulatory system—circulating
tumour cells (CTCs)—encounter capillary beds, where they start the process of …

Lamin A/C provides a nuclear scaffold for compartmentalization of genome function that is
important for genome integrity. Lamin A/C dysfunction is associated with cancer, aging, and …