Systems genetics approaches for understanding complex traits with relevance for human disease
Quantitative traits are often complex because of the contribution of many loci, with further
complexity added by environmental factors. In medical research, systems genetics is a …
complexity added by environmental factors. In medical research, systems genetics is a …
Which mouse multiparental population is right for your study? The Collaborative Cross inbred strains, their F1 hybrids, or the Diversity Outbred population
GR Keele - G3: Genes, Genomes, Genetics, 2023 - academic.oup.com
Multiparental populations (MPPs) encompass greater genetic diversity than traditional
experimental crosses of two inbred strains, enabling broader surveys of genetic variation …
experimental crosses of two inbred strains, enabling broader surveys of genetic variation …
Species-wide quantitative transcriptomes and proteomes reveal distinct genetic control of gene expression variation in yeast
EM Teyssonnière, P Trébulle… - Proceedings of the …, 2024 - National Acad Sciences
Gene expression varies between individuals and corresponds to a key step linking
genotypes to phenotypes. However, our knowledge regarding the species-wide genetic …
genotypes to phenotypes. However, our knowledge regarding the species-wide genetic …
[HTML][HTML] Cell morphology QTL reveal gene by environment interactions in a genetically diverse cell population
C O'Connor, GR Keele, W Martin, T Stodola, D Gatti… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Genetically heterogenous cell lines from laboratory mice are promising tools for population-
based screening as they offer power for genetic mapping, and potentially, predictive value …
based screening as they offer power for genetic mapping, and potentially, predictive value …
Chromosome X Dosage Modulates Development of Aneuploidy in Genetically Diverse Mouse Embryonic Stem Cells
The genetic integrity of pluripotent stem cells (PSC) is integral to their applications in
research and therapy, but it is compromised by frequent development of copy number …
research and therapy, but it is compromised by frequent development of copy number …
An in vitro neurogenetics platform for precision disease modeling in the mouse
The power and scope of disease modeling can be markedly enhanced through the
incorporation of broad genetic diversity. The introduction of pathogenic mutations into a …
incorporation of broad genetic diversity. The introduction of pathogenic mutations into a …